Results 51 to 60 of about 4,043,886 (303)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Greedy Algorithm for Deriving Decision Rules from Decision Tree Ensembles

Entropy
This study introduces a greedy algorithm for deriving decision rules from decision tree ensembles, targeting enhanced interpretability and generalization in distributed data environments.
Evans Teiko Tetteh, Beata Zielosko
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Pembentukan Model Pohon Keputusan pada Database Car Evaluation Menggunakan Statistik Chi-Square

Contemporary Mathematics and Applications (ConMathA), 2022
The study discusses problems related to the formation of a decision tree based on a collection of evaluation data records obtained from a number of car buyers. This secondary data was obtained from the UCL machine learning website.
Retno Maharesi
doaj   +1 more source

Extension of Decision Tree Algorithm for Stream Data Mining Using Real Data [PDF]

, 2009
Recently, because of increasing amount of data in the society, data stream mining targeting large scale data has attracted attention. The data mining is a technology of discovery new knowledge and patterns from the massive amounts of data, and what the ...
Konishi, Osamu, Minegishi, Tatsuya, Niimi, Ayahiko, Ise, Masayuki   +3 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Decision tree analysis for prostate cancer prediction [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. The use of serum prostate-specific antigen (PSA) test has dramatically increased the number of men undergoing prostate biopsy. However, the best possible strategies for selecting appropriate patients for prostate biopsy have yet ...
Stojadinović Miroslav M., Stojadinović Milorad M., Pantić Damjan N.   +2 more
doaj   +1 more source

On Explaining Decision Trees

CoRR, 2020
Decision trees (DTs) epitomize what have become to be known as interpretable machine learning (ML) models. This is informally motivated by paths in DTs being often much smaller than the total number of features. This paper shows that in some settings DTs can hardly be deemed interpretable, with paths in a DT being arbitrarily larger than a PI ...
Yacine Izza, Alexey Ignatiev, João Marques-Silva 0001   +2 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Decision tree-based Design Defects Detection

IEEE Access, 2021
Design defects affect project quality and hinder development and maintenance. Consequently, experts need to minimize these defects in software systems. A promising approach is to apply the concepts of refactoring at higher level of abstraction based on ...
Mohamed Maddeh, Sarra Ayouni, Sultan Alyahya, Fahima Hajjej   +3 more
doaj   +1 more source