Results 111 to 120 of about 368,305 (304)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Control de inventarios y su importancia en la toma de decisiones gerenciales
, 2017 El artículo resalta la importancia del sistema de control de los inventarios como un mecanismo de minimización de riesgos organizacionales y su impacto en la toma de decisiones gerenciales.
Sierra Sierra, Carlos Efraín
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
LA EDUCACIÓN Y LOS FINES ESENCIALES DEL ESTADO. DEBERES, DERECHOS Y RESPONSABILIDADES. UNIVERSIDAD Y SERVICIO EDUCATIVO [PDF]
, 2004 Abordar la problemática de la educación como fin esencial del Estado ha sido siempre un desafió, fundamentalmente por la sinergia que supone el constante cambio de paradigmas que condicionan el lugar que ocupan alternativamente la noción del propio ...
Efrón, Marcelo Héctor
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
DerecomCon un estilo al alcance de todos los públicos, Nexus propone una amplia reflexión sobre los retos que trae consigo la inteligencia artificial, una de las disrupciones más profundas de la historia de la humanidad, tal vez por encima del nacimiento de la
José Carlos Cámara Molina
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Análisis de los procesos de pensamiento y toma de decisiones interactivas de profesores de E.G.B
, 2018 Este artículo se centra en el estudio de los procesos de pensamiento y toma de decisiones de los profesores durante la enseñanza interactiva. El paradigma de «Pensamientos del Profesor» se asume y describe desde la perspectiva del modelo de toma de ...
Marcelo García, Carlos
core +1 more source
Transformational leadership and decision-making in organizations of the Colombian Caribbean
Dictamen LibreThe objective of the research was to analyze transformational leadership and decision-making in organizations in the Colombian Caribbean, based on a methodology with a quantitative, descriptive approach, non-experimental, cross-sectional, and field ...
Camilo Barragán Morales +3 more
doaj +1 more source