Results 111 to 120 of about 258,248 (308)

La intuición estratégica en la toma de decisiones

, 2011
El análisis, y particularmente la toma de decisiones, siempre han constituido objeto de estudio para los investigadores. Este campo disciplinario, genéricamente, puede denominarse: ciencia y análisis de las decisiones.
Flores Martínez, Larissa Lissette
core  

Percepciones, decisiones y Relaciones Internacionales: Los márgenes operativos perceptivos aceptables

, 2012
El significado de la realidad internacional depende en buena medida de dos aspectos político-psicológicos, a saber: las decisiones y las percepciones. Las primeras modelan el entorno y las segundas condicionan a las primeras.
Rubén Herrero
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Transformational leadership and decision-making in organizations of the Colombian Caribbean

Dictamen Libre
The objective of the research was to analyze transformational leadership and decision-making in organizations in the Colombian Caribbean, based on a methodology with a quantitative, descriptive approach, non-experimental, cross-sectional, and field ...
Camilo Barragán Morales, Adriana Pomares Mendoza, Milicen Borja Barrera, Fabian Márquez Osorio   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Aplicación de la teoría de los sistemas sociales en empresas camagüeyanas

Retos de la Dirección, 2014
La escuela de los sistemas sociales, pese a no ser muy conocida en el contexto cubano, potencia, a través del trabajo de los principales autores, el diseño y formulación de los objetivos así como el proceso de toma de decisiones.
Yenly Betancourt Borrero, Néstor Loredo Carballo , Guberto Canovas Riverón   +2 more
doaj  

Análisis de los procesos de pensamiento y toma de decisiones interactivas de profesores de E.G.B

, 2018
Este artículo se centra en el estudio de los procesos de pensamiento y toma de decisiones de los profesores durante la enseñanza interactiva. El paradigma de «Pensamientos del Profesor» se asume y describe desde la perspectiva del modelo de toma de ...
Marcelo García, Carlos
core