Results 101 to 110 of about 258,248 (308)

Control de inventarios y su importancia en la toma de decisiones gerenciales

, 2017
El artículo resalta la importancia del sistema de control de los inventarios como un mecanismo de minimización de riesgos organizacionales y su impacto en la toma de decisiones gerenciales.
Sierra Sierra, Carlos Efraín
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Decisiones de inversión de los caficultores colombianos [PDF]

, 2015
En esta investigación se realizan experimentos de campo contextualizado para analizar el efecto de la disponibilidad de dinero y los retardos en la toma de decisiones de inversión de pequeños caficultores colombianos.
Acevedo Sánchez, Yuliana
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Reseña de Azares y decisiones. Recuerdos personales

, 2019
Twenty years after the publication of An ‘Autobiography of Emotion, Mind, and Spirit’ (1999) by the humanist-phenomenological geographer Yi-Fu Tuan, Horacio Capel surprises us with ‘Azares y decisiones.
Pillet Capdepón, Félix
core  

Planificación, seguimiento y enfoque de procesos, en la mejora de la UNC [PDF]

, 2007
El presente artículo analiza algunas aplicaciones de conceptos y recursos propios de la gestión de calidad, implementadas en distintas dependencias de la UNC.
Zanazzi, José Francisco, Cámara, María Cecilia, Zanazzi, José Luis   +2 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Criterios para la toma de decisiones en los procesos inversionistas

Revista Centro Azúcar, 2011
Se realizó, a través de encuestas, una valoración del nivel de conocimientos y de consenso existente entre los especialistas del municipio Camagüey, sobre el conjunto de criterios que se tienen en cuenta en un proceso previo inversionista, determinándose
Amaury Pérez Martínez, Erenio González Suárez, Hilda Oquendo Ferrer, Pablo Galindo Llanes   +3 more
doaj