Results 81 to 90 of about 258,248 (308)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CUERPOS COLEGIADOS UNIVERSITARIOS: ¿FUNCIONALES A LOS ÓRGANOS PERSONALES DE GOBIERNO DE LAS UNSE? [PDF]

, 2011
El Estatuto de nuestra Institución menciona dentro de sus órganos de gobierno a: La Asamblea Universitaria (órgano máximo); el Honorable Consejo Superior; El Rector; los Consejos Directivos de las Facultades y Los Decanos.
Arguelles, Cristina B.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

¿Qué se valora del bosque nativo y cómo se pueden restaurar los agroecosistemas? Percepciones y preferencias de productores agrícola-ganaderos del Espinal, al sureste de Córdoba

Ecología Austral
Los agroecosistemas son socioecosistemas en los que las personas perciben, valoran y se benefician con los bienes y servicios que proporciona la naturaleza; además, la modifican en función de sus preferencias y decisiones.
Malena Villarruel Parma, Fernando Zamudio, Esteban Kowaljow   +2 more
doaj   +1 more source

Uso de las TIC para las condiciones de Gobernabilidad, con énfasis en el ámbito de la gestión universitaria [PDF]

, 2007
En los hechos cotidianos de las prácticas administrativas hay concepciones dicotómicas entre los modos de construir políticas institucionales. Por una parte, las que se aferran a las formas tradicionales de administración y rechazan las TICs, y por otra ...
Salmerón, Doctorando Eduardo
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

PROSPECTIVE AND SCORECARD, A STRATEGIC WEAPON AGAINST ENVIRONMENTAL CHANGES

Anuario Facultad de Ciencias Económicas y Empresariales, 2016
Until the decade of the 70 the nucleus of the concern in companie´s bussiness management was constituted it the achievement of the efficiency, a very important economic condition, but with the turbulence of the environment this condition was necessary ...
María del C. Herrero-Infante, Yanet Mora-Herrero   +1 more
doaj  

Variante del método promethee para decisiones multicriterio discretas

Costos y Gestión
Existen dos grandes divisiones en las situaciones de toma de decisiones con múltiples obje­tivos: programación multiobjetivo, referido a variables continuas, y decisiones multicriterio discretas. El trabajo se centra en la problemática de las decisiones
Raúl Alberto Ercole, Claudia Beatriz Peretto   +1 more
doaj   +1 more source