Results 81 to 90 of about 23,934 (260)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Transformational leadership and decision-making in organizations of the Colombian Caribbean
Dictamen LibreThe objective of the research was to analyze transformational leadership and decision-making in organizations in the Colombian Caribbean, based on a methodology with a quantitative, descriptive approach, non-experimental, cross-sectional, and field ...
Camilo Barragán Morales +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Aplicación de la teoría de los sistemas sociales en empresas camagüeyanas
Retos de la Dirección, 2014 La escuela de los sistemas sociales, pese a no ser muy conocida en el contexto cubano, potencia, a través del trabajo de los principales autores, el diseño y formulación de los objetivos así como el proceso de toma de decisiones.
Yenly Betancourt Borrero +2 more
doaj
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Probabilidad e incertidumbre, una aproximación desde la historia del pensamiento
Revista de Economía Institucional, 2016 La incertidumbre en sentido radical no es probabilística, pero como no hay una noción de probabilidad única esta definición general es insuficiente. El artículo presenta en forma histórica las definiciones equiprobabilista, frecuentista y bayesiana de ...
Mario García Molina
doaj +2 more sources
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source