Results 161 to 170 of about 24,911 (203)

Decitabine-Driven Foetal Haemoglobin Induction in Townes Mice and Human Erythroblasts. [PDF]

open access: yesEJHaem
Carol Illa A   +6 more
europepmc   +1 more source

Increasing TET expression and 5-hydroxymethylcytosine formation by a carbocyclic 5-aza-2’-deoxy-cytidine antimetabolite

open access: yes
Däther M   +17 more
europepmc   +1 more source

Decitabine

Reactions Weekly, 2009
The pyrimidine analogs, 5-azacytidine (azacitidine, Vidaza) and its deoxy derivative, 5-aza-2'-deoxycytidine (decitabine, Dacogen, are the most widely used inhibitors of DNA methylation which trigger demethylation leading to a consecutive reactivation of epigenetically silenced tumor suppressor genes in vitro and in vivo.
Daskalakis, Michael   +2 more
  +6 more sources

Decitabine

Reactions Weekly, 2014
Besides 5-azacytidine (azacitidine, Vidaza®), 5-aza-2'-deoxycytidine (decitabine, Dacogen®) is the most widely used inhibitor of DNA methylation, which triggers demethylation leading to consecutive reactivation of epigenetically silenced tumor suppressor genes in vitro and in vivo.
Hackanson, Björn, Daskalakis, Michael
openaire   +4 more sources

Decitabine

Drugs, 2006
Decitabine is a hypomethylating agent. Its action in DNA leads to the reactivation of tumour suppressor genes and the subsequent differentiation of cancer cells. In a randomised, phase III trial in patients (n = 170) with myelodysplastic syndromes (MDS), intravenous decitabine (45 mg/m(2)/day for 3 consecutive days every 6 weeks) combined with ...
Kate, McKeage, Katherine F, Croom
openaire   +2 more sources

Decitabine

Current Opinion in Oncology, 2003
Decitabine is a cytosine analogue synthesized in the 1960s that is currently enjoying a revival of interest prompted by the elucidation of DNA methylation inhibition as its major mechanism of action, along with increased understanding of the role of DNA methylation in epigenetic dysregulation in cancer.
openaire   +2 more sources

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