Results 31 to 40 of about 30,536 (239)

Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia

Journal for ImmunoTherapy of Cancer, 2021
Background The powerful ‘graft versus leukemia’ effect thought partly responsible for the therapeutic effect of allogeneic hematopoietic cell transplantation in acute myeloid leukemia (AML) provides rationale for investigation of immune-based therapies ...
Meghali Goswami, Gege Gui, L. Dillon, K. Lindblad, Julie Thompson, Janet Valdez, Dong-Yun Kim, J. Ghannam, K. Oetjen, C. DeStefano, Dana M Smith, H. Tekleab, Yeusheng Li, Pradeep K. Dagur, Thomas E. Hughes, J. Marté, Jaydira Del Rivero, Joanna Klubo-Gwiezdzinksa, J. Gulley, K. Calvo, Catherine Lai, C. Hourigan   +21 more
semanticscholar   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
A Balmain, AJ Boivin, B Hendrich, BC Richardson, C Anacleto, C Grunau, CA Eads, E Bair, E Papouli, EE Cameron, F Lyko, G Egger, G Gifford, G Strathdee, G Strathdee, HG Chang, J Hall, J M Teodoridis, J Tra, JA Plumb, JF Costello, JG Herman, JM Teodoridis, JM Teodoridis, JP Issa, K Yamashita, L Zhang, LA Loeb, M Daskalakis, M Esteller, M Esteller, M Esteller, M Lachner, M Toyota, ME Valk-Lingbeek, MF Paz, MF Paz, MM Gottesman, MS Soengas, NP Bhattacharyya, PJ Johnson, PM Warnecke, R Agarwal, R Brown, R Brown, R M Glasspool, S Fulda, SH Wei, SH Wei, SL Gerson, SM Taylor, SW Lowe, T Taniguchi, T Ushijima, TH Huang, W Fischle, Y Pommier, Z Xiong   +57 more
core   +2 more sources

Increased levels of DNA methyltransferases are associated with the tumorigenic capacity of prostate cancer cells [PDF]

, 2012
DNA methylation might be the earliest somatic genome changes in prostate cancer that also play an important role in the process of tumor invasion, growth and metastasis.
D'Alessandro, Anna Maria, Di Clemente, Luigi, Di Pasquale, Boris, Dolo, Vincenza, Festuccia, Claudio, Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Muzi, Paola, Ranieri, Guido   +9 more
core   +1 more source

Inhibition of DNA methyltransferase leads to increased genomic 5-hydroxymethylcytosine levels in hematopoietic cells. [PDF]

, 2018
5-Hydroxymethylcytosine (5hmC) is produced from 5-methylcytosine (5mC) by Ten-eleven translocation (TET) dioxygenases. The epigenetic modification 5hmC has crucial roles in both cellular development and differentiation.
Apró, Anna, Arányi, Tamás, Bacquet, Caroline, Hathy, Edit, Kiss, Judit, Réthelyi, János M., Szabó, Pál, Szeri, Flóra, Szüts, Dávid, Vető, Borbála   +9 more
core   +4 more sources

Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer

eJHaem, 2020
MLL‐rearranged acute lymphoblastic leukemia (ALL) represents a highly aggressive ALL subtype, characterized by aberrant DNA methylation patterns. DNA methyltransferase inhibitors, such as decitabine have previously been demonstrated to be effective in ...
Pauline Schneider, Patricia Garrido Castro, Sandra M. Pinhanços, Mark Kerstjens, Eddy H. vanRoon, Anke H.W. Essing, M. Emmy M. Dolman, Jan J. Molenaar, Rob Pieters, Ronald W. Stam   +9 more
doaj   +1 more source

Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]

, 2014
BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo, Gupta, Sanjay, Hong, David, Issa, Jean-Pierre, Jelinek, Jaroslav, Kurzrock, Razelle, Nunez, Maria I, Stewart, David J, Wistuba, Ignacio I   +8 more
core   +3 more sources

Oral cedazuridine/decitabine: a phase 2, pharmacokinetic/pharmacodynamic, randomized, crossover study in MDS and CMML.

Blood, 2020
This phase 2 study was designed to compare systemic decitabine exposure, demethylation activity, and safety in the first 2 cycles with cedazuridine 100 mg/decitabine 35 mg vs standard decitabine 20 mg/m2 IV.
G. Garcia-Manero, E. Griffiths, D. Steensma, G. Roboz, R. Wells, J. Mccloskey, O. Odenike, A. Dezern, K. Yee, L. Busque, C. O'Connell, L. Michaelis, J. Brandwein, H. Kantarjian, A. Oganesian, M. Azab, M. Savona   +16 more
semanticscholar   +1 more source

MTSS1 is a critical epigenetically regulated tumor suppressor in CML [PDF]

, 2015
Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr ...
Braunschweig, T., Brümmendorf, T. H., Chatain, N., Copland, M., Costa, I. G., Gusmao, E. G., Haenzelmann, S., Hamilton, A., Helgason, G.V., Herrmann, O., Holyoake, T. L., Kintsler, S., Koschmieder, S., Li, S., Merle Reher, M., Müller-Tidow, C., Schemionek, M., Schubert, C., Schwab, A.   +18 more
core   +1 more source

Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: Long term follow‐up from a phase 1b study

American journal of hematology/oncology, 2020
This analysis represents the longest‐term follow‐up for patients with acute myeloid leukemia (AML) treated with 400 mg of venetoclax plus azacitidine or decitabine. Adults with newly diagnosed AML ineligible for intensive chemotherapy were enrolled in an
D. Pollyea, K. Pratz, A. Letai, B. Jonas, A. Wei, V. Pullarkat, M. Konopleva, M. Thirman, M. Arellano, P. Becker, B. Chyla, W. Hong, Q. Jiang, J. Potluri, C. Dinardo   +14 more
semanticscholar   +1 more source

Pharmacokinetics and pharmacodynamics of an oral formulation of decitabine and tetrahydrouridine.

European Journal of Haematology, 2023
BACKGROUND Sickle cell disease (SCD) is caused by an inherited structural abnormality of adult hemoglobin causing polymerization. Fetal hemoglobin interferes with polymerization but is epigenetically silenced by DNA methyltransferase 1 (DNMT1) in adult ...
H. Lau, P. Woost, U. Friedrich, W. Clausen, James W. Jacobberger, Y. Saunthararajah   +5 more
semanticscholar   +1 more source