Results 31 to 40 of about 24,911 (203)
Increased levels of DNA methyltransferases are associated with the tumorigenic capacity of prostate cancer cells [PDF]
, 2012 DNA methylation might be the earliest somatic genome changes in prostate cancer that also play an important role in the process of tumor invasion, growth and metastasis.
D'Alessandro, Anna Maria +9 more
core +1 more source
Decitabine rescues cisplatin resistance in head and neck squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC) reduces survival. In this study we hypothesized that methylation of key genes mediates cisplatin resistance.
Chi T Viet +5 more
doaj +1 more source
Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia
Haematologica, 2014 Hypomethylating agents are widely used in patients with myelodysplastic syndromes and unfit patients with acute myeloid leukemia. However, it is not well understood why only some patients respond to hypomethylating agents.
Haiyang Yun +13 more
doaj +1 more source
npj Breast Cancer, 2023 TROP2 antibody drug conjugates (ADCs) are under active development. We seek to determine whether we can enhance activity of TROP2 ADCs by increasing TROP2 expression.
Ming Zhao +12 more
doaj +1 more source
The history of oral decitabine/cedazuridine and its potential role in acute myeloid leukemia
Therapeutic Advances in Hematology, 2023 Decitabine, a member of the 5-azanucleosides, has a dose-dependent mechanism of action in vitro : termination of DNA replication at high doses, and inhibition of DNA methyltransferase at low doses.
Robert Briski +3 more
doaj +1 more source
Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]
, 2018 The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core +1 more source
Epigenetics in Friedreich's ataxia: Challenges and opportunities for therapy [PDF]
, 2013 Copyright © 2013 Chiranjeevi Sandi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Al-Mahdawi, S, Pook, MA, Sandi, C
core +2 more sources
Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study [PDF]
, 2015 OBJECTIVE: Plasma miRNAs represent potential minimally invasive biomarkers to monitor and predict outcomes from chemotherapy. The primary goal of the current study-consisting of patients with recurrent, platinum-resistant ovarian cancer-was to ...
Benson, Eric A. +4 more
core +8 more sources
Advances in Hematology, 2015 Introduction. The incidence of Acute Myeloid Leukemia (AML) increases progressively with age and its treatment is challenging. This prospective case control study was undertaken to compare the safety, efficacy, and cost-effectiveness of decitabine with ...
Linu A. Jacob +6 more
doaj +1 more source
Journal of International Medical Research, 2022 Objective Combination therapy has become the hallmark of lung cancer treatment, as it reduces the dosage intensity of individual drugs while increasing their efficacy.
Maoyi Xu +3 more
doaj +1 more source