Results 61 to 70 of about 24,911 (203)

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, EarlyView.
What's New? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway

Frontiers in Immunology, 2020
Organ dysfunction caused by sepsis is life-threatening and results in high mortality. Therapeutic options for sepsis are limited. Pathogenic factors are considered as components of environmental pressure that modify DNA methylation patterns thereby ...
Luxi Cao, Luxi Cao, Luxi Cao, Luxi Cao, Luxi Cao, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Xiabing Lang, Xiabing Lang, Xiabing Lang, Xiabing Lang, Xiabing Lang, Sha Jia, Sha Jia, Sha Jia, Sha Jia, Sha Jia, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Ping Zhang, Ping Zhang, Ping Zhang, Ping Zhang, Ping Zhang, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +59 more
doaj   +1 more source

Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria‐Induced Apoptosis Pathway

Journal of Clinical Laboratory Analysis, EarlyView.
Inhibition of XPO1 is a promising modality in the treatment of MDS, especially when combined with Venetoclax, which activates mitochondria‐mediated apoptosis and could be a potential target for MDS therapy. ABSTRACT Background Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies that pose a serious health threat.
Xiaohan Liu, Lei Huang, Junzhu Wang, Yixuan Guo, Hongli Shen, Xianghong Zhao, Lanzhu Yue, Zhaoyun Liu, Rong Fu   +8 more
wiley   +1 more source

Synergistic Therapeutic Effects of Low Dose Decitabine and NY-ESO-1 Specific TCR-T Cells for the Colorectal Cancer With Microsatellite Stability

Frontiers in Oncology, 2022
Patients of colorectal cancer (CRC) with microsatellite stability (MSS) show poor clinical response and little beneficial result from the immune-checkpoint inhibitors, due to the ‘cold’ tumor microenvironment.
Ganjun Yu, Wenying Wang, Xiaobo He, Jia Xu, Rongrong Xu, Tao Wan, Yanfeng Wu   +6 more
doaj   +1 more source

Decitabine Increases the Transcription of RIG-I Gene to Suppress the Replication of Feline Calicivirus and Canine Influenza Virus

Microorganisms
Developing novel antiviral drugs has always been a significant forefront in biological medicine research. Antiviral drugs can be extracted, purified, and synthesized from various biological sources and by different methods.
Shaotang Ye, Zhen Wang, Aolei Chen, Ying Chen, Gaoming Lou, Qingmei Xie, Gang Lu, Shoujun Li   +7 more
doaj   +1 more source

Comparison of the effects of olsalazine and decitabine on the expression of CDH1 and uPA genes and cytotoxicity in MDA-MB-231 breast cancer cells

Research in Pharmaceutical Sciences, 2021
Background and purpose: Since DNA methyltransferase enzymes play a key role in DNA methylation, they can be used as a target to alter epigenetic changes and treat cancer.
Misagh Mohammadi Asl, Javad Mohammadi Asl, Mojgan Naghitorabi   +2 more
doaj   +1 more source

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy [PDF]

, 2017
Despite advancements in cancer therapeutics, acute myeloid leukemia patients over 60 years old have a 5-year survival rate of less than 8%. In an attempt to improve this, epigenetic modifying agents have been combined as therapies in clinical studies. In
Clarke, Kathryn M., Kettyle, Laura M., Mills, Ken I., Thompson, Alexander, Young, Christine S.   +4 more
core   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia

International Journal of Nanomedicine, 2017
Thomas Briot,1,2 Emilie Roger,1 Nolwenn Lautram,1 Alexis Verger,1 Anne Clavreul,3,4 Frederic Lagarce1,2 1Micro & Nanomédecines Translationelles – MINT, UNIV Angers, INSERM 1066, CNRS 6021, Université Bretagne Loire, MINT IBS-CHU,
Briot T, Roger E, Lautram N, Verger A, Clavreul A, Lagarce F   +5 more
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