Results 81 to 90 of about 78,373 (324)

Deep-space navigation with differenced data types. Part 3: An expanded information content and sensitivity analysis [PDF]

open access: yes, 1992
An approximate six-parameter analytic model for Earth-based differential range measurements is presented and is used to derive a representative analytic approximation for differenced Doppler measurements.
Estefan, J. A., Thurman, S. W.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

M2000 : an astrometric catalog in the Bordeaux Carte du Ciel zone +11 degrees < {delta} < +18 degrees

open access: yes, 2001
During four years, systematic observations have been conducted in drift scan mode with the Bordeaux automated meridian circle in the declination band [+11 ; +18].
B. Viateau   +23 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Association Between the Morphology of Proximal Tibiofibular Joint and the Presence of Knee OA

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
Objective: The aim of this study was to evaluate the association between the morphology of the proximal tibiofibular joint (PTFJ) and the presence of knee osteoarthritis (OA).Methods: Twenty-eight OA subjects and 30 healthy subjects were enrolled in this
Xin-Zheng Qi   +9 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Declination and Segmentation in Children with Childhood Apraxia of Speech

open access: yesLanguages
Childhood apraxia of speech (CAS) is characterized by atypical timing between segments, leading to prosodic disruption at the lexical level. This study tested whether prosodic impairment in CAS extends to the intonational level by examining declination ...
Jill C. Thorson   +4 more
doaj   +1 more source

Necessity and Chance in Marx's Doctoral Thesis [PDF]

open access: yesحکمت و فلسفه
According to Marx's interpretation, in the Democritean system, atoms move in a vacuum according to a blind necessity. Applying the word "accidental" to the Democritus system does not imply the unpredictable or causeless movement of atoms; rather, it ...
Ali Karbasizadeh Esfahani, Milad Omrani
doaj   +1 more source

Seeing Earth's Orbit in the Stars: Parallax and Aberration

open access: yes, 2012
During the 17th century the idea of an orbiting and rotating Earth became increasingly popular, but opponents of this view continued to point out that the theory had observable consequences that had never, in fact, been observed.
Hirshfeld Alan   +2 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy