Results 91 to 100 of about 76,673 (303)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Declination and Segmentation in Children with Childhood Apraxia of Speech

Languages
Childhood apraxia of speech (CAS) is characterized by atypical timing between segments, leading to prosodic disruption at the lexical level. This study tested whether prosodic impairment in CAS extends to the intonational level by examining declination ...
Jill C. Thorson, Rachel T. Babcock, Julia M. Fisher, Kirrie J. Ballard, Donald A. Robin   +4 more
doaj   +1 more source

Necessity and Chance in Marx's Doctoral Thesis [PDF]

حکمت و فلسفه
According to Marx's interpretation, in the Democritean system, atoms move in a vacuum according to a blind necessity. Applying the word "accidental" to the Democritus system does not imply the unpredictable or causeless movement of atoms; rather, it ...
Ali Karbasizadeh Esfahani, Milad Omrani
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ground-based absolute magnetic survey on the backbone network of points of the secular passage in Ukraine for the era of 2005

Геофизический журнал, 2010
The results of the geomagnetic field components on renewed Ukrainian repeat stations (RS) network are considered. The methods of absolute geomagnetic and astro-geodetic measurements are described, as well as methods of geomagnetic field reduction to ...
V. Yu. Maksimchuk, M. I. Orlyuk, V. I. Tregubenko, Yu. M. Gorodiski, V. P. Myasoedov, E.F. Nakalov   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Analysis of Aerothermal Environment Characteristics of Hypersonic Rudder Shaft Gaps

气体物理
Rudder shaft gaps of hypersonic vehicles affect the flow structure and corresponding aerodynamic heating characteristics, resulting in local peak heating near the rudder shaft, which poses a safety risk to the local thermal protection system.
Zhiyi REN, Fuguo BIAN, Zongyang LI, Xiao SHI, Tuo LIU   +4 more
doaj   +1 more source

Model magnetne deklinacije za Slovenijo ; The model of magnetic declination of Slovenia [PDF]

Geodetski Vestnik, 2012
Predstavljen je polinomski model magnetne deklinacije za območje Slovenije, ki zaradi svojega lokalnega značaja omogoča točnejše izračunavanje deklinacije, kot je to mogoče s svetovnimi modeli. Podlaga za izračun koeficientov modela so vrednosti magnetne
Dalibor Radovan, Tomaž Žagar
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Smart Façades: Declination with the Electrochromic Glass

Challenging Glass Conference Proceedings, 2016
Energy saving and environmental protection don’t represent only a technical problem but also, and maybe most of all, an ethical problem. From this point of view, the Mediterranean area, characterized by a considerable Sunshine for at least 8 months a ...
G. Loddo, D. Ludoni
doaj   +1 more source