Results 111 to 120 of about 76,673 (303)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Comparison of the reference mark azimuth determination methods

Annals of Geophysics, 2013
The knowledge of the azimuth of the reference mark is of crucial importance in the determination of the declination which is defined as the ellipsoidal (geodetic) azimuth of the geomagnetic meridian.
Danijel Šugar, Mario Brkić, Drago Špoljarić   +2 more
doaj   +1 more source

Sky reconstruction from transit visibilities: PAON-4 and Tianlai Dish Array

, 2016
The spherical harmonics $m$-mode decomposition is a powerful sky map reconstruction method suitable for radio interferometers operating in transit mode. It can be applied to various configurations, including dish arrays and cylinders.
Ansari, Reza, Campagne, Jean-Eric, Chen, Xuelei, Magneville, Christophe, Wu, Fengquan, Zhang, Jiao   +5 more
core   +3 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Distance to Orion KL Measured with VERA

, 2007
We present the initial results of multi-epoch VLBI observations of the 22 GHz H2O masers in the Orion KL region with VERA (VLBI Exploration of Radio Astrometry).
Bushimata, Takeshi, Choi, Yoon Kyung, Hirota, Tomoya, Honma, Mareki, Imai, Hiroshi, Iwadate, Kenzaburo, Jike, Takaaki, Kameno, Seiji, Kameya, Osamu, Kamohara, Ryuichi, Kan-ya, Yukitoshi, Kawaguchi, Noriyuki, Kijima, Masachika, Kim, Mi Kyoung, Kobayashi, Hideyuki, Kuji, Seisuke, Kurayama, Tomoharu, Manabe, Seiji, Maruyama, Kenta, Matsui, Makoto, Matsumoto, Naoko, Miyaji, Takeshi, Nagayama, Takumi, Nakagawa, Akiharu, Nakamura, Kayoko, Oh, Chung Sik, Omodaka, Toshihiro, Oyama, Tomoaki, Sakai, Satoshi, Sasao, Tetsuo, Sato, Katsuhisa, Sato, Mayumi, Shibata, Katsunori M., Shintani, Motonobu, Tamura, Yoshiaki, Tsushima, Miyuki, Yamashita, Kazuyoshi   +36 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A Gaia-PS1-SDSS (GPS1) Proper Motion Catalog Covering 3/4 of the Sky

, 2017
We combine Gaia DR1, PS1, SDSS and 2MASS astrometry to measure proper motions for 350 million sources across three-fourths of the sky down to a magnitude of $m_r\sim20$\,.
Goldman, Bertrand, Gupta, Prashansa, Kudritzki, Rolf-Peter, Liu, Chao, Martin, Nicolas F., Platais, Imants, Rix, Hans-Walter, Sesar, Branimir, Tian, Hai-Jun, Waters, Christopher Z.   +9 more
core   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source