Results 71 to 80 of about 12,962 (271)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
MORPHOLOGICAL OVERLAPPINGS OF SYSTEMS IN GERMAN AND CROATIAN LANGUAGE [PDF]
Hum, 2011 Morphological differences between languages, here concretely between German and Croatian, appear because of differences in systems and therefore it is extremely important to examine genetic-linguistic any typological characteristics of their systems ...
Marinko Pandžić
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
L’antropotecnica e le sue declinazioni in Sloterdijk (Anthropotechnics and its declinations in Sloterdijk) [PDF]
Polis: Revista de Stiinte Politice, 2016 Sloterdijk considers human beings to be the only beings that have succeeded in detaching themselves from the evolutionary development of their own species by means of a new way of relating with the environment that surrounds them.
Maria Teresa PANSERA
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
34th European Dendroecological Fieldweek 2024 - Report
Forest@The 34th European Dendroecological Fieldweek was held in Bardonecchia (TO), Italy, from August 23rd to 30th. The European Dendroecological Fieldweek is a summer school for students and young researchers interested in exploring and deepening the theme of ...
Maimone F, Gamba R, Bono A
doaj +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
, 2011 We present 474 new proper motion stellar systems in the southern sky having no previously known components, with 0.40" yr^-1 > mu >= 0.18" yr^-1 between declinations -47 deg and 00 deg. In this second paper utilizing the U.S.
Boyd, M. R. +4 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source