Results 101 to 110 of about 1,264,100 (295)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Ecology and Society, 2011 This paper operationalizes the concept of highly optimized tolerance (HOT) for the case of smallholder agriculture in Rondônia, Brazil. It seeks to understand how characteristics of family farms shift as a function of property size, arguing that as ...
Andrew Reid. Bell
doaj
A local quantum version of the Kolmogorov theorem
, 2004 Consider in $L^2 (\R^l)$ the operator family $H(\epsilon):=P_0(\hbar,\omega)+\epsilon Q_0$. $P_0$ is the quantum harmonic oscillator with diophantine frequency vector $\om$, $Q_0$ a bounded pseudodifferential operator with symbol holomorphic and ...
Bambusi +11 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A note on monotonicity property of Bessel functions
International Journal of Mathematics and Mathematical Sciences, 1997 A theorem of Lorch, Muldoon and Szegö states that the sequence {∫jα,kjα,k+1t−α|Jα(t)|dt}k=1∞ is decreasing for α>−1/2, where Jα(t) the Bessel function of the first kind order α and jα,k its kth positive root.
Stamatis Koumandos
doaj +1 more source
Concave Renewal Functions Do Not Imply DFR Inter-Renewal Times
, 2010 Brown (1980, 1981) proved that the renewal function is concave if the inter-renewal distribution is DFR (decreasing failure rate), and conjectured the converse. This note settles Brown's conjecture with a class of counter-examples.
Szekli, Yaming Yu
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Wicking Behaviors of Ring and Compact-Siro Ring Spun Yarns with Different Twists
AUTEX Research Journal, 2019 In this study, the wicking properties of ring and compact-siro ring spun staple yarns were compared. The twist level, which is related to the structure of the staple yarns, was found to significantly influence the wicking property of the two kinds of ...
Lu Yuzheng, Wang Yang, Gao Weidong
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source