Results 101 to 110 of about 741,460 (300)
Taxation and systematic risk under decreasing returns to scale [PDF]
, 2003 Lund (2002a) showed in a CAPM-type model how tax depreciation schedules affect required expected returns after taxes. Even without leverage higher tax rates implied lower betas when tax deductions were risk free.
Lund, Diderik
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Scale properties in data envelopment analysis [PDF]
Recently there has been some discussion in the literature concerning the nature of scale properties in the Data Envelopment Model (DEA). It has been argued that DEA may not be able to provide reliable estimates of the optimal scale size. We argue in this
Olesen, Ole Bent +1 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Efficiency Analysis of Indonesian Sharia Banks
AFEBI Islamic Finance and Economic Review, 2019 The development of Islamic banking in Indonesia is still not optimal, so it requires performance improvement. It is necessary to measure efficiency and productivity to achieve predetermined targets.
Nur Khalimah, Edy Yusuf Agung Gunanto
doaj
Social wellbeing as a criterion of structural policy efficiency
Ученые записки Российской академии предпринимательства, 2021 Social wellbeing of nation is not only a constitutional goal of the state, but, above all, the quintessence of all large-scale economic and political transformations.
E. U. Dotsenko +2 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Advances in Civil EngineeringThe purpose of this study is to explore the deformation characteristics of existing stations caused by large-scale excavation in reclaimed areas. By comprehensively employing theoretical analysis, numerical simulation, and field measurements, it conducts
Manpo Zhao, Fenghai Ma, Zhang Guo
doaj +1 more source