Results 61 to 70 of about 741,460 (300)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Analysis on Residual Oxide Scale of Picked Spring Steel Coil and Measures of Process Improvement

Teshugang, 2017
The examination and analysis on thickness, structure and composition of surface residual oxide scale of Φ14mm and Φ16mm coii of spring steel (/%：0.58C, 1.66Si, 0.78Mn, 0.006P, 0.004S) have been carried out by using optical microscope and scanning ...
戴永刚, 宋云霞, 郑永瑞, 刘会杰   +3 more
doaj  

Stabilization of ion-scale electrostatic drift-type modes with decreasing aspect ratio through major or minor radius in tokamaks

Nuclear Fusion
In the conventional tokamak with a high aspect ratio ( A ), turbulent transport is known to be dominated by the ion-scale electrostatic drift-type modes, such as the ion temperature gradient (ITG) or trapped electron mode (TEM). When tokamak type changes
J.Y. Kim, H.S. Han
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

STRUKTUR BIAYA DAN SKALA USAHA EKONOMIS PENGGILINGAN KOPI BUBUK DI KOTA BENGKULU

Jurnal Agrisep, 2009
The coffee has an economic prospective for Bengkulu PDRB since it is regional key commodity. But limitation of capital, production technology, and market information have made this business on stagnation condition. The research is aimed to elaborate the
M. Mustopa Romdhon
doaj   +1 more source

Hardening and softening mechanisms at decreasing microstructural length scales

Philosophical Magazine, 2008
A laminate structure with varying laminae thicknesses is used as a qualitative model of grain size dependence on yield behaviour in metallic materials. Both strain gradient plasticity and slip between layers are considered. It is shown that an inverse Hall--Petch effect can be generated in this way.
Dahlberg, Carl Fredrik Oscar, Gudmundson, Peter   +1 more
openaire   +2 more sources