Results 41 to 50 of about 1,896 (262)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The impact of error dependencies on Ring/Mod-LWE/LWR based schemes [PDF]

, 2019
Current estimation techniques for the probability of decryption failures in Ring/Mod-LWE/LWR based schemes assume independence of the failures in individual bits of the transmitted message to calculate the full failure rate of the scheme.
Verbauwhede, Ingrid, Jan-Pieter D’Anvers, Vercauteren, Frederik, Jan-Pieter D\u27Anvers, Frederik Vercauteren, D'Anvers, Jan-Pieter, Ingrid Verbauwhede   +6 more
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Design of Rabin-like cryptosystem without decryption failure [PDF]

, 2016
In this work, we design a new, efficient and practical Rabin-like cryptosystem without using the Jacobi symbol, redundancy in the message and avoiding the demands of extra information for finding the correct plaintext.
Kamel Ariffin, Muhammad Rezal, Asbullah, Muhammad Asyraf   +1 more
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Combinatorial Rank Attacks Against the Rectangular Simple Matrix Encryption Scheme [PDF]

, 2020
In 2013, Tao et al. introduced the ABC Simple Matrix Encryption Scheme, a multivariate public key encryption scheme. The scheme boasts great efficiency in encryption and decryption, though it suffers from very large public keys. It was quickly noted that
Dustin Moody, Javier Verbel, Daniel Smith-Tone, Daniel Apon, Ray Perlner   +4 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Rabin-RZ: a new efficient method to overcome Rabin cryptosystem decryption failure problem [PDF]

, 2014
We propose a new efficient method to overcome the 4 to 1 decryption failure for the Rabin cryptosystem by reducing the phase space of plaintext from M ε ℤ to M ε 22n-2, 22n-1 ⊂ ℤpq, where pq is a product of 2 strong primes and pq ε 22n, 22n+2. Instead of
Kamel Ariffin, Muhammad Rezal, Mahad, Zahari   +1 more
core  

Blockchain-based distributed EHR fine-grained traceability scheme

Tongxin xuebao, 2021
Aiming at the key management of electronic health records (EHR) in a distributed system and user identity tracing issues, a distributed EHR fine-grained traceability scheme based on blockchain was proposed.Combining chameleon hash and zero-knowledge ...
Zuobin YING, Yuanping SI, Jianfeng MA, Ximeng LIU   +3 more
doaj   +2 more sources