Results 31 to 40 of about 678 (218)
Le dieu Mars en Afrique, une enquête épigraphique
Antiquités Africaines, 2022 In this paper the purpose is to answer a few questions such as, for example: the cult of Mars in Africa is or is not interested in phenomena of syncretism or assimilation?
Cecilia Ricci
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Hera and the Sea. Decoding Dedications at the Samian Heraion [PDF]
Studia Hercynia, 2019 The paper examines the Near Eastern and Greek dedications at the Sanctuary of Hera in Samos during the 8th to 6th centuries BC. Contextualising the types of dedications and their origins indicate the identity of the dedicators, and whether they were ...
Hannah L. Ringheim
doaj
Women’s work: The dedication of loom weights in the sanctuaries of southern Italy
Pallas, 2011 Loom weights are a common find in the sanctuaries of the ancient world. These small, portable, and inexpensive objects, however, are often marginalised in scholarship as merely remnants of weaving that took place at the site, or as low status dedications.
Alexandra Sofroniew
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Nouvelles dédicaces d’Alésia à Apollon Moritasgus
Gallia, 2016 Three new dedications to Apollo Moritasgus are published here which belong to the god’s sanctuary on the eastern edge of Alesia. The first one comes from Espérandieu’s old excavations, in 1910.
Olivier de Cazanove +1 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source