Results 71 to 80 of about 1,193,111 (325)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Capacity and Distribution of Water Stored in the Vadose Zone of the Chinese Loess Plateau
Vadose Zone Journal, 2019 Water stored in the vadose (unsaturated) zone provides the majority of water required by plants and buffers water resources; thus, it is central to understanding ecological and hydrological processes in the Chinese Loess Plateau (CLP) with its thick ...
Yuanjun Zhu +7 more
doaj +1 more source
Energy Reports, 2022 The inherent anisotropy of shale makes it exhibit different mechanical properties when measured in different directions. Generally, the measurements of the anisotropic mechanical properties of shale are generally conducted on cylindrical samples, and the
Rui He +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
A Comparative Assessment of Mid-Water Trawl and Deep Vision for Investigating Fishery Resources in the Coastal Waters off Jeju Island, Korea [PDF]
, 2022 Yong-Deuk Lee +5 more
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
How should diverse stakeholder interests shape evaluations of complex water resources systems robustness when confronting deeply uncertain changes? [PDF]
, 2023 Sai Veena Sunkara +4 more
openalex +3 more sources
Mechanical behaviors and rupture processes of a typical granitic stratum
Journal of Rock Mechanics and Geotechnical EngineeringGranitic veins (GVs) have a significant influence on the mechanical responses of tunnels excavated in granitic strata. Distinguishing the mechanical properties of host granites (HGs), GVs and vein-granite interfaces (VGIs) is critical.
Xiaofang Nie +8 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Advances in Mechanical Engineering, 2023 During tunnel excavation using a tunnel boring machine (TBM), the interaction between the cutter and the rock causes the cutterhead to generate abrupt vibrations, which could lead to engineering problems, such as bearing seal failure and even cutterhead ...
Zhenxing Yang +5 more
doaj +1 more source