Results 101 to 110 of about 317,965 (338)

Adaptive deep brain stimulation in a freely moving parkinsonian patient [PDF]

, 2015
The future of deep brain stimulation (DBS) for Parkinson\u2019s disease (PD) lies in new closed-loop systems that continuously supply the implanted stimulator with new settings obtained by analyzing a feedback signal related to the patient\u2019s ...
Ardolino, Gianluca, Arlotti, Mattia, Cogiamanian, Filippo, Cortese, Francesca, Di Fonzo, Alessio, Marceglia, Sara Renata Francesca, Priori, Alberto, Rampini, Paolo M., Rosa, Manuela   +8 more
core   +1 more source

Quantitative Iron Measurements in the Basal Ganglia of NBIA Patients Using QSM: Insights From a Tertiary Center

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurodegeneration with brain iron accumulation (NBIA) comprises rare genetic disorders characterized by predominantly extrapyramidal symptoms and iron deposition in the basal ganglia. Conventional magnetic resonance imaging (MRI) detects qualitative changes but cannot accurately quantify iron accumulation. Quantitative susceptibility
Özge Uygun, Alpay Özcan, Fuat Kaan Aras, Evrim Bozdemir, Sibel Uğur İşeri, Murat Gültekin, Nihan Hande Akçakaya, Orkhan Mammadov, Gülay Kır, Dilek İnce Günal, Neşe Tuncer, Fatma Betül Özdilek, Banu Özen Barut, Ercan Köse, Hülya Apaydın, Asuman Ali, Sultan Çağırıcı, Pınar Topaloğlu, Alp Dinçer, Zuhal Yapıcı   +19 more
wiley   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Nucleus accumbens deep brain stimulation in adult patients suffering from severe and enduring anorexia nervosa (STIMARS): protocol for a pilot study

Frontiers in Psychiatry
BackgroundAffecting adolescent and young adults, anorexia nervosa (AN) has the highest death rate of all mental disorders. Effective treatment options are lacking and a significant proportion of patients develop severe and chronic forms of the disease ...
Philibert Duriez, Philibert Duriez, Giorgia Antonia Simboli, Giorgia Antonia Simboli, Philippe Domenech, Philippe Domenech, Philippe Domenech, Anne Buot, Anne Buot, Casey Halpern, Casey Halpern, Marie Fadigas, Yann Mongin, Aurore Guy-Rubin, Romain Carron, Romain Carron, Catherine Oppenheim, Catherine Oppenheim, Philip Gorwood, Philip Gorwood, Johan Pallud, Johan Pallud, Marc Zanello, Marc Zanello   +23 more
doaj   +1 more source

Partial improvement in performance of patients with severe Alzheimer's disease at an early stage of fornix deep brain stimulation

Neural Regeneration Research, 2018
Deep brain stimulation is a therapy for Alzheimer's disease (AD) that has previously been used for mainly mild to moderate cases. This study provides the first evidence of early alterations in performance induced by stimulation targeted at the fornix in ...
Zhi-Qi Mao, Xin Wang, Xin Xu, Zhi-Qiang Cui, Long-Sheng Pan, Xiao-Jing Ning, Bai-Xuan Xu, Lin Ma, Zhi-Pei Ling, Jian-Jun Jia, Xin-Guang Yu   +10 more
doaj   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report

Journal of Medical Case Reports, 2011
Background The neuroleptic malignant syndrome is an uncommon but dangerous complication characterized by hyperthermia, autonomic dysfunction, altered mental state, hemodynamic dysregulation, elevated serum creatine kinase, and rigor.
Stavrinou Lampis C, Boviatsis Efstathios J, Themistocleous Marios S, Stathis Pantelis, Sakas Damianos E   +4 more
doaj   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Deep Brain Stimulation

, 2009
Publisher Summary This chapter focuses on the surgical technique used during deep brain stimulation (DBS). Although there are reports of successful DBS surgery performed completely under general anesthesia, DBS is typically performed under conscious sedation or local anesthesia, in order to provide awake physiologic confirmation of the target ...
Ali R. Rezai, Alon Y. Mogilner, Andre G. Machado   +2 more
openaire   +5 more sources

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source