Results 61 to 70 of about 2,777,952 (193)

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source

Receiver operating characteristic (ROC) curves for discrimination of diseased from healthy eyes.

, 2018
Legends show area under the ROC curve and 95% confidence interval. SCP: macular superficial capillary plexus; DCP: macular deep capillary plexus; RCP: peripapillary radial capillary plexus.
Maria Vittoria Cicinelli (5501984), Paolo Bettin (5870639), Francesco Bandello (750203), Giuseppe Querques (2267224), Alessandro Rabiolo (3360854), Riccardo Sacconi (3360863), Giacinto Triolo (5870636), Francesco Gelormini (5870633), Kouros Nouri-Mahdavi (5870642)   +8 more
core   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Inter-rater reliability of the manual method for the entire cohort, DR and glaucoma patients.

, 2018
**** significant at p < 0.0001; *** significant at p < 0.001; ** significant at p < 0.01; NS: not significant; DR: diabetic retinopathy; ICC: intraclass correlation coefficient; op: operator; SCP: macular superficial capillary plexus; DCP: macular deep ...
Maria Vittoria Cicinelli (5501984), Paolo Bettin (5870639), Francesco Bandello (750203), Giuseppe Querques (2267224), Alessandro Rabiolo (3360854), Riccardo Sacconi (3360863), Giacinto Triolo (5870636), Francesco Gelormini (5870633), Kouros Nouri-Mahdavi (5870642)   +8 more
core   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Vessel density values of superficial plexus, deep plexus and choriocapillaris.

, 2017
Vessel density values of superficial plexus, deep plexus and choriocapillaris.
Rodolfo Mastropasqua (840601), Marta Di Nicola (325339), Enrico Borrelli (750198), Luca Di Antonio (840603), Peter A. Mattei (139979), Lisa Toto (840602), Alfonso Senatore (3712747), Cesare Mariotti (3712750)   +7 more
core   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Deep and superficial OCT angiography changes after macular peeling: idiopathic vs diabetic epiretinal membranes

, 2017
To assess changes in deep and superficial perifoveal capillary plexus after macular peeling in idiopathic and diabetic epiretinal membrane (iERM and dERM, respectively)
ROSSI, CLAUDIA, Sparnelli, Federica, SCHIEMER, STEFANO, ROMANO, MARIO, CENNAMO, GILDA, CENNAMO, GIOVANNI   +5 more
core   +1 more source

Innervation of the tubarial glands: A hypothesis‐driven anatomical review

The Anatomical Record, EarlyView.
Abstract The tubarial glands have been described as a macroscopic bilateral glandular complex in the posterolateral nasopharynx near the torus tubarius and the pharyngeal opening of the Eustachian tube. Since their recognition on prostate‐specific membrane antigen‐based imaging, their anatomical classification has remained debated, with converging ...
Mugurel Constantin Rusu, Ivan Varga, Răzvan Costin Tudose   +2 more
wiley   +1 more source

Retinal Vascular Degeneration in the Transgenic P23H Rat Model of Retinitis Pigmentosa

Frontiers in Neuroanatomy, 2018
Retinitis pigmentosa (RP) is a group of inherited retinal degenerative diseases involving a progressive degeneration of photoreceptor cells. Following the loss of photoreceptors, retinal vascularization tends to decrease, which seems to play a role in ...
Laura Fernández-Sánchez, Gema Esquiva, Isabel Pinilla, Isabel Pinilla, Pedro Lax, Nicolás Cuenca, Nicolás Cuenca   +6 more
doaj   +1 more source