Results 181 to 190 of about 693,698 (310)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Combining Gabor-local and contextual-global deep features for cholesteatoma classification. [PDF]

Sci Prog
Chen J, Zhang G, Wang Y, Sun Y.
europepmc   +1 more source

A hybrid approach for diagnosing diabetic retinopathy from fundus image exploiting deep features. [PDF]

Heliyon, 2023
Mahmood MAI, Aktar N, Kader MF.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Graph-enhanced multimodal fusion of vascular biomarkers and deep features for diabetic retinopathy detection. [PDF]

Front Artif Intell
Deepsahith KV, Shashank B, Kumar B, Alphonse S, Subburaj B, Subramanian G.   +5 more
europepmc   +1 more source

The classification of wheat yellow rust disease based on a combination of textural and deep features. [PDF]

Multimed Tools Appl, 2023
Hayıt T, Erbay H, Varçın F, Hayıt F, Akci N.   +4 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

A Hybrid Lung and Colon Histopathological Image Classification Framework Using MobileNetV3-Small Deep Features and Differential Evolution Optimization. [PDF]

Diagnostics (Basel)
Naveed MU, Jabbar S, Iqbal MM, Ahmad A, Alkhazi IS, Alghamdi M.   +5 more
europepmc   +1 more source

OralNet: Fused Optimal Deep Features Framework for Oral Squamous Cell Carcinoma Detection. [PDF]

Biomolecules, 2023
Mohan R, Rama A, Raja RK, Shaik MR, Khan M, Shaik B, Rajinikanth V.   +6 more
europepmc   +1 more source