Cannabinoid Receptor Agonist WIN55, 212-2 Attenuates Injury in the Hippocampus of Rats after Deep Hypothermic Circulatory Arrest [PDF]
Brain Sciences, 2023 Objectives: Postoperative neurological deficits remain a challenge in cardiac surgery employing deep hypothermic circulatory arrest (DHCA). This study aimed to investigate the effect of WIN55, 212-2, a cannabinoid agonist, on brain injury in a rat model ...
Ming-Huan Yu +6 more
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Neuropsychologic outcome after deep hypothermic circulatory arrest in adults [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 1999 Pediatric patients undergoing prolonged periods of deep hypothermic circulatory arrest have been found to experience long-term deficits in cognitive function. However, there is limited information of this type in adult patients who are undergoing deep hypothermic circulatory arrest for thoracic aortic repairs.One hundred forty-nine patients undergoing ...
Reich, David L. +9 more
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MicroRNA expression in the hippocampal CA1 region under deep hypothermic circulatory arrest [PDF]
Neural Regeneration Research, 2019 Using deep hypothermic circulatory arrest, thoracic aorta diseases and complex heart diseases can be subjected to corrective procedures. However, mechanisms underlying brain protection during deep hypothermic circulatory arrest are unclear.
Xiao-Hua Wang +9 more
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Effect of Deep Hypothermic Circulatory Arrest Versus Moderate Hypothermic Circulatory Arrest in Aortic Arch Surgery on Postoperative Renal Function: A Systematic Review and Meta‐Analysis [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Moderate hypothermic circulatory arrest (MHCA) has been widely used in aortic arch surgery. However, the renal function after MHCA remains controversial. We performed a systematic review and meta‐analysis direct comparison of the postoperative
Liang Cao +5 more
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Retrograde cerebral perfusion reduces embolic and watershed lesions after acute type a aortic dissection repair with deep hypothermic circulatory arrest [PDF]
Journal of Cardiothoracic SurgeryBackground To assess whether retrograde cerebral perfusion reduces neurological injury and mortality in patients undergoing surgery for acute type A aortic dissection.
Jacob Ede +9 more
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Effects of different doses of ulinastatin on organ protection of deep hypothermic circulatory arrest in rats [PDF]
Journal of Cardiothoracic SurgeryBackground Deep hypothermic circulatory arrest (DHCA) can cause systemic inflammatory response (SIR) and ischemia-reperfusion (I/R) injury, potentially exacerbating organ failure. Ulinastatin (UTI) is a frequently employed anti-inflammatory medication in
Yuan Teng +7 more
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CircFRRS1 drives neuroinflammation through the miR-27a-3p/TLR4 pathway after deep hypothermic circulatory arrest [PDF]
Frontiers in Cellular NeuroscienceNeurologic injury remains a critical complication of deep hypothermic circulatory arrest (DHCA) in aortic arch surgery, with neuroinflammation driven by multiple factors in its pathogenesis.
Weidong Yan +9 more
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Deep hypothermic circulatory arrest
Continuing Education in Anaesthesia Critical Care & Pain, 2010 The cardiopulmonary bypass (CPB) circuit must be primed with a fluid solution. The volume of prime required is either based on a standard empirically derived volume greater than a minimum safe priming volume, or may be guided by the patient's weight or body surface area. The initial hematocrit (HCT) achieved after initiation of CPB is determined by the
Sarah Conolly +2 more
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Intrathecal morphine in two patients undergoing deep hypothermic circulatory arrest during aortic surgery -A case report- [PDF]
Korean Journal of Anesthesiology, 2012 We retrospectively report the first use of intrathecal morphine prior to incision in two male patients undergoing a complex aortic reconstruction, who required complete circulatory arrest under deep hypothermia for intraoperative and postoperative pain ...
Rene Przkora +3 more
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Metabolites, 2022 Neonates undergoing cardiac surgery involving aortic arch reconstruction are at an increased risk for hypoxic-ischemic brain injury. Deep hypothermia is utilized to help mitigate this risk when periods of circulatory arrest are needed for surgical repair.
Tiffany S. Ko +20 more
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