Results 131 to 140 of about 1,138,724 (269)

Multi-prior physics-enhanced neural network enables pixel super-resolution and twin-image-free phase retrieval from single-shot hologram

Opto-Electronic Advances
Digital in-line holographic microscopy (DIHM) is a widely used interference technique for real-time reconstruction of living cells’ morphological information with large space-bandwidth product and compact setup.
Xuan Tian, Runze Li, Tong Peng, Yuge Xue, Junwei Min, Xing Li, Chen Bai, Baoli Yao   +7 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

LUNA: Loss-Construct Unsupervised Network Adjustment for Low-Dose CT Image Reconstruction

IEEE Access
Reconstructing low-dose CT imaging deals with handling the inherent noise within the data, which makes it a complex mathematical problem known as an ill-posed inverse problem.
Ritu Gothwal, Shailendra Tiwari, Shivendra Shivani   +2 more
doaj   +1 more source

Simultaneous Denoising of Dynamic PET Images Based on Deep Image Prior. [PDF]

J Digit Imaging, 2022
Yang CH, Huang HM.
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Hybrid Reconstruction Approach for Polychromatic Computed Tomography in Highly Limited-Data Scenarios

Sensors
Conventional strategies aimed at mitigating beam-hardening artifacts in computed tomography (CT) can be categorized into two main approaches: (1) postprocessing following conventional reconstruction and (2) iterative reconstruction incorporating a beam ...
Alessandro Piol, Daniel Sanderson, Carlos F. del Cerro, Antonio Lorente-Mur, Manuel Desco, Mónica Abella   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Direct Reconstruction of Linear Parametric Images From Dynamic PET Using Nonlocal Deep Image Prior. [PDF]

IEEE Trans Med Imaging, 2022
Gong K, Catana C, Qi J, Li Q.
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source