Results 181 to 190 of about 2,902,010 (219)

Panmixia in a Widespread Butterfly: High Dispersal and Ecological Generalism Buffer Against Landscape Fragmentation

Ecology and Evolution, Volume 16, Issue 9, September 2026.
The study examined the genetic structure of Pieris rapae across western Germany and found no genetic differentiation or isolation by distance. Fragmented agricultural landscapes did not reduce genetic connectivity compared to more heterogeneous systems, indicating near‐panmixia across the region.
Praveen Dhyani, Franziska Deppe, Klaus Fischer   +2 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Alexandros Makis, Ioanna Saougou, Eleftheria Hatzimichael   +2 more
wiley   +1 more source

Identification of Novel Pathogenic Variants in Familial Adenomatous Polyposis Through Whole Genome Sequencing. [PDF]

Hum Mutat
Choi SR, Kim MJ, Ku JL, Jeong SY, Choi M, Park JW.   +5 more
europepmc   +1 more source

The Germline SH2B3rs111340708 Splicing Variant Drives Intron Retention and Protein Instability by Impacting Clinical Outcomes in Core Binding Factor AML

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT The SH2B3 gene, also known as LNK, encodes an adaptor protein that negatively regulates key hematopoietic signaling pathways, including JAK–STAT, MAPK, and PI3K/AKT, thereby maintaining hematopoietic homeostasis. SH2B3 interacts with major signaling regulators such as JAK2, MPL, FLT3, and KIT. Loss‐of‐function alterations have been reported in
Marta Rachele Stefanucci, Livia Leuzzi, Linda Montavoci, Davide Paolo Bernasconi, Luca Cimaschi, Alessandra Trojani, Anna Caretti, Lorenzo Del Castello, Roberto Cairoli, Alessandro Beghini   +9 more
wiley   +1 more source

From Single Cells to Diagnosis: Proteomics Technologies in the Multi‐Omics Landscape of Rare and Mitochondrial Diseases

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
Wetzel et al. outline how individual omics methods contribute to the diagnosis of patients with rare, and particularly mitochondrial diseases, with a focus on how spatial proteomics is joining this multi‐omics stack. ABSTRACT Proteomics by mass spectrometry has rapidly matured from a niche method into a standard tool.
Simon Wetzel, Sebastian Porsdam Mann, Florian A. Rosenberger   +2 more
wiley   +1 more source

A deep intronic IFT172 variant causing pseudoexon inclusion identified by whole-genome sequencing in nephronophthisis. [PDF]

CEN Case Rep
Sy PM, Baba M, Fujiwara K, Yamamura N, Kawato K, Nishi E, Aoyama S, Kimura Y, Inoki Y, Nagano C, Sakakibara N, Horinouchi T, Yamamura T, Ishimori S, Morisada N, Nozu K.   +15 more
europepmc   +1 more source

Current Evidence for Circulating Tumor DNA in Sarcoma: Challenges and Opportunities for Clinical Application

Journal of Surgical Oncology, Volume 134, Issue 4, Page 490-501, September 15, 2026.
ABSTRACT Sarcomas represent a diverse group of mesenchymal tumors with high rates of recurrence after resection. While recent technical advances have enabled the detection of rare circulating tumor DNA (ctDNA) in other malignancies, the complexity and heterogeneity of sarcoma genomics have historically limited ctDNA in these cancers.
Kristin E. Goodsell, Jason A. Carter, Hannah R. Abrams, Harveshp Mogal, Elizabeth T. Loggers, Jeremy Sharib   +5 more
wiley   +1 more source

Diagnostic Yield of Genome Sequencing in an Iranian Exome-Negative Autosomal-Recessive Intellectual Disability Cohort. [PDF]

Hum Mutat
Shokouhian E, Moslemi M, Moghadam MG, Molaei N, Alagha P, Reshadmanesh A, Arzhangi S, Ghodratpour F, Celik M, Kadioglu IS, Edizadeh M, Akbari MR, Kahrizi K, Najmabadi H.   +13 more
europepmc   +1 more source

Genetic Association Studies in Hepatocellular Carcinoma: Systematic Meta‐Analyses, a Comprehensive Field Synopsis, and Epidemiological Evidence

MedComm, Volume 7, Issue 9, September 2026.
Based on meta‐analyses and cumulative epidemiological evidence, the present study identifies 11 genetic variants in 11 genes that are truly associated with the risk of hepatocellular carcinoma. Our work presents a systematic synopsis, which helps elucidate the mechanisms of carcinogenesis and provides insights into the early diagnosis and novel ...
Yujin Shi, Bin Huang, Xiaohong Liu, Yalan Liu, Qinyong Hu, Tianyu Lei, Luqi Tang, Guanglin Xiao, Tingting Ning, Shengqin Yue, Jiahui He, Qilian Du, Xuanmei Li, Yixuan Zhou, Qiongfang Zhang, Chunyan Qi, Hong Ren, Hong‐Gang Ren   +17 more
wiley   +1 more source