Results 181 to 190 of about 65,281 (258)

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

open access: yesAnnals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff   +3 more
wiley   +1 more source

Research progress of artificial intelligence in high-throughput drug screening. [PDF]

open access: yesFront Pharmacol
Liu X   +8 more
europepmc   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

open access: yesAdvanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia   +10 more
wiley   +1 more source

Turning a new leaf: PhenoVision provides leaf phenology data at the global scale

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Premise Plant phenology dictates many aspects of community function and ecosystem dynamics. Yet, global phenology data are still limited, especially in areas lacking monitoring programs. Here we present a new data resource, PhenoVision–Leaf, which extends a computer vision pipeline utilizing iNaturalist digital image vouchers to produce global‐
Erin L. Grady   +6 more
wiley   +1 more source

Leveraging Big Multitemporal Multisource Satellite Data and Artificial Intelligence for the Detection of Complex and Invisible Features: The Case of Extensive Irrigation Mapping

open access: yesArchaeological Prospection, EarlyView.
ABSTRACT The detection of buried or obscured archaeological features remains a central challenge in landscape archaeology, particularly in the irrigated floodplains of Mesopotamia where levees and canals formed the basis of complex agrarian systems. This study presents a deep learning–based approach for the large‐scale, automated detection of ancient ...
Nazarij Buławka   +4 more
wiley   +1 more source

Deep learning in the early diagnosis of acute aortic dissection. [PDF]

open access: yesFront Cardiovasc Med
Eggleton S, Ryan J, Gallego B.
europepmc   +1 more source

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