Results 141 to 150 of about 20,723,044 (331)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Gulf of Alaska 2004: Forests of the Deep [PDF]

In this activity, students explore deep-sea coral communities associated with seamounts. They will be able to explain at least three ways in which seamounts are important to biological communities, infer at least three ways in which deep-sea corals are ...

core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Unveiling the role of industries for European financial stability. Insights from the energy sector

Journal of Business Economics and Management
Extensive analysis of intertwinement with other industries caused the energy sector to gain momentum in the recent economic literature. This paper aims to create an indicator that captures the impact of financial stability for energy companies on all ...
Iulia Lupu, Radu Lupu, Adina Criste
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Estimating urban noise levels from Multi-Scale and Multi-Spectral remote sensing imagery

International Journal of Applied Earth Observations and Geoinformation
Establishing a high-quality urban sound environment is essential for the sustainable development of modern cities. Estimating the noise pollution levels in urban areas is integral to improving the overall well-being of city dwellers.
Zhihong Chen, Teng Fei, Jing Xiao, Jing Huang, Dunxin Jia, Meng Bian   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gestation in patients with high levels of anticardiolipin antibodies, a history of deep venous thrombosis and miscarriages

Archives of Medical Science, 2006
The aim is to stress the importance of prophylaxis against deep venous thrombosis in gravidas with high levels of anticardiolipin antibodies with or without a history of repetitive miscarriages.
José Maria Pereira de Godoy, Ligia Cosentino Junqueira Franco Spegiorin, Juliana Dallaqua, Cecília Freire de Carvalho de Carvalho, Iara Lima Costa   +4 more
doaj  

Optical coherence tomography angiography findings in hypertensive patients

Delta Journal of Ophthalmology
Purpose This study was designed to assess the macular retinal and choroidal microvascular abnormalities in hypertensive patients with hypertensive retinopathy using optical coherence tomography angiography (OCT-A).
Khaled A. El Sheikh, Hamdy A. El-Koumy, Tamer Wasfy, Amin E. Nawar   +3 more
doaj   +1 more source