Results 71 to 80 of about 18,988 (294)
A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes
Advanced Science, EarlyView.We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen +13 more
wiley +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Carbon Free Boston: Energy Technical Report [PDF]
, 2019 Part of a series of reports that includes: Carbon Free Boston: Summary Report; Carbon Free Boston: Social Equity Report; Carbon Free Boston: Technical Summary; Carbon Free Boston: Buildings Technical Report; Carbon Free Boston: Transportation ...
Cleveland, Cutler J. +4 more
core
Advanced Science, EarlyView.Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl +27 more
wiley +1 more source
Bi-level Optimal Scheduling of Wind-Solar-Hydro-Thermal Multi-Energy Complementary System Considering Pumped Storage [PDF]
长江科学院院报[Objective] In response to the operational challenge caused by high penetration of wind and solar power in modern power systems, this study aims to propose a bi-level optimized scheduling model for a multi-energy complementary power generation system ...
YAN Xin-jun, WANG Hong-xu
doaj +1 more source
Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy +16 more
wiley +1 more source
Flexibility Transformation Analysis of 350 MW Supercritical Cogeneration Unit
发电技术, 2018 In recent years, the wind and PV power curtailment is becoming more and more serious, and the demand for deep peaking capacity of coal-fired power plants is also increasing.
Shuming LI +4 more
doaj +1 more source
Vehicle-to-Grid - What is the Benefit for a Sustainable Mobility? [PDF]
The demand for vehicles in industrialised countries is dropping and the growth rate in developing countries is slowing down rapidly. Driver of this evolution is evidently the current crisis but also the expectation that in the long run oil will not be ...
Guy Fournier +2 more
core
District heating and cooling optimization and enhancement – towards integration of renewables, storage and smart grid [PDF]
, 2017 District heating and cooling (DHC) systems are attracting increased interest for their low carbon potential. However, most DHC systems are not operating at the expected performance level.
Li, Yu, Rezgui, Yacine, Zhu, Hanxing
core +2 more sources
Advanced Science, EarlyView.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source