Results 101 to 110 of about 398,081 (284)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A source-load collaborative stochastic optimization method considering the electricity price uncertainty and industrial load peak regulation compensation benefit

International Journal of Electrical Power & Energy Systems
Energy-intensive industrial load offers substantial capacity and rapid adjustment capabilities, which can be effectively coordinated with deep peak regulation (DPR) methods of thermal power to optimize the peak regulation state of the system.
Xiaoyu Yue, Lijun Fu, Siyang Liao, Jian Xu, Deping Ke, Huiji Wang, Shuaishuai Feng, Jiaquan Yang, Xuehao He   +8 more
doaj   +1 more source

Research on methods and scale of deeply exploitable hydropower resources [PDF]

E3S Web of Conferences
Deep development of hydropower is an important measure to optimize the structure of clean energy, meet the peak shaving and backup needs of the power system, and achieve the national dual carbon goals.
Wang Fei, Liu Yusheng, Li Qilong, Xu Da, Yu Jialiang   +4 more
doaj   +1 more source

Intensification of work-place regimes in British agriculture: the role of migrant workers [PDF]

, 2006
In Britain, international migrants have very recently become the major workforce in labour-intensive agriculture. This paper explores the causes of the dramatic increase since the 1990s in the employment of migrant workers in this sub-sector.
Rogaly, Ben
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The ATS-6 power system: Hardware implementation and orbital performance [PDF]

The Applications Technology Satellite-6 power system, a shunt-boost configuration, uses partial shunt regulation of the solar array and a boost regulator for control of battery power.
Hornbuckle, F. L., Lavigna, T. A.
core   +1 more source

Spatial distribution of local tunneling conductivity due to interference and Coulomb interaction effects for deep and shallow impurities on semiconductor surfaces

, 2010
Spatial distribution of local tunneling conductivity was investigated for deep and shallow impurities on semiconductor surfaces. Non-equilibrium Coulomb interaction and interference effects were taken into account and analyzed theoretically with the help
Arseev, Arseev, Dombrowski, Fano, Gores, Hofstetter, Inglesfield, Keldysh, Madhavan, Mahieu, Mantsevich, Maslova, Maslova, N.S. Maslova, Sullivan, V.N. Mantsevich   +15 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs. [PDF]

, 2019
Maintenance of high-turnover tissues such as the epidermis requires a balance between stem cell proliferation and differentiation. The molecular mechanisms governing this process are an area of investigation.
Chen, Yifang, Harismendy, Olivier, Jones, Jackson, Li, Jingting, Ling, Ji, Sen, George L, Tiwari, Manisha, Wang, Ying, Xu, Xiaojun   +8 more
core   +1 more source