Results 61 to 70 of about 398,081 (284)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Unit commitment with bidirectional ramping constraints of flexibility retrofit thermal power unit

International Journal of Electrical Power & Energy Systems
Flexibility retrofits of thermal power units have been widely implemented to improve power system balancing. These retrofits enable operation below the regular minimum output, known as deep peak regulation, to accommodate increasing renewable energy ...
Jingxiao Jiang, Yanran Zhu, Ying Wang, Xiaorui Guo, Jianhu Lv, Jianxiang Qin, Xingyun Yan, Kaifeng Zhang   +7 more
doaj   +1 more source

Study on the suppression effect of variable hydrogen parameters on the temperature rise of the turbo‐generator rotor under deep peak regulation

IET Electric Power Applications, 2023
In recent years, the extensive participation of turbine generator in deep peak regulation has caused significant damage to the rotor windings, which is rooted in the frequent and significant changes in the electrical load of the rotor, accompanied by ...
Yucai Wu, Yingjie Guo
doaj   +1 more source

Compensation Model of Deep Peak Load Regulation of Thermal Power Units with Flexibility Reform

DEStech Transactions on Environment, Energy and Earth Sciences, 2017
In the face of the increasingly severe situation of peak load regulation, this paper establishes a compensation model of deep peak load regulation of thermal power units which is beneficial to the flexibility reform and the active participation in the system's deep peak load regulation of thermal power units.
Hai-xia WANG, Zi-cheng ZHOU, Bin GUI, Quan LV, Wei-dong LI   +4 more
openaire   +2 more sources

Optimization of Bi-Directional V2G Behavior With Active Battery Anti-Aging Scheduling [PDF]

, 2020
The bi-directional linkage between the power grid and electric vehicles (EVs) enables flexible, cheap and fast-responding use of vehicle batteries in the grid. However, the battery aging effects due to the additional operation cycles caused by Vehicle-to-
Li, Jianwei, Li, Shuangqi, Su, Chang, Yang, Qingqing   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Two-Layer Optimal Scheduling and Economic Analysis of Composite Energy Storage with Thermal Power Deep Regulation Considering Uncertainty of Source and Load

Energies
A two-layer scheduling method of energy storage that considers the uncertainty of both source and load is proposed to coordinate thermal power with composite energy storage to participate in the peak regulation of power systems.
Chao Xing, Jiajie Xiao, Xinze Xi, Jingtao Li, Peiqiang Li, Shipeng Zhang   +5 more
doaj   +1 more source

Carbon Free Boston: Buildings Technical Report [PDF]

, 2019
Part of a series of reports that includes: Carbon Free Boston: Summary Report; Carbon Free Boston: Social Equity Report; Carbon Free Boston: Technical Summary; Carbon Free Boston: Transportation Technical Report; Carbon Free Boston: Waste Technical ...
Best, Rob, Calven, Alexandra, Castigliego, Joshua R., Cleveland, Cutler J., Hatchadorian, Rebecca, Levine, Erica, Perez, Taylor, Pollack, Adam, Swett, Brian, Tepfer, Sara, Walsh, Michael J., Wholey, Katie   +11 more
core