Results 201 to 210 of about 107,403 (262)

Revised oceanic molybdenum isotope budget from deep-sea pelagic sediments. [PDF]

Nat Commun
Wang Z, Li J, Hu B, Zou L, Ding X, Zhang L, Ma J, Wei G.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The false promise of deep-sea mining. [PDF]

NPJ Ocean Sustain
Alger J, Green JF, Neville KJ, Park S, VanDeveer SD, Webster DG.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Deep-sea mining discharge can disrupt midwater food webs. [PDF]

Nat Commun
Dowd MH, Assad VE, Cazares-Nuesser AE, Drazen JC, Goetze E, White AE, Popp BN.   +6 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Method for the Intelligent Identification of the Operating Conditions of Deep-Sea Submersibles and Its Application. [PDF]

Sensors (Basel)
Zhang Y, Li Z, Tang J, He K.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Correction to "Ecological Impacts of Deep-Sea Mining Waste on Marine Algae and Copepod <i>Tigriopus californicus</i>". [PDF]

Environ Sci Technol
Thomson C, Lough AJM, Moorkens J, Liu T, Gunnells SA, Fitzsimmons JN, Steiner Z, Dunlea AG, Woulds C, Homoky WB, Wang M, Tan QG, Liu F.   +12 more
europepmc   +1 more source

Sequencing Ultraconserved Elements (UCEs) for Marine Population Genomics: A Proof-of-Concept Using a Deep-Sea Mussel Species. [PDF]

Evol Appl
Li YX, Xu T, Perez M, Chen C, Watanabe HK, Ip JC, Qiu JW.   +6 more
europepmc   +1 more source