Results 191 to 200 of about 204,461 (310)

Genomic analysis of an extremophile PLS47 from a deep-sea vent. [PDF]

Front Microbiol
Furqan BRN, Widhiastuty MP, Febriani, Afifah DN, Iqbalsyah TM, Akhmaloka.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

New Cytotoxic Anthraquinone Derivatives from a Deep-Sea-Derived <i>Aspergillus</i> sp. SCSIO 41331. [PDF]

Mar Drugs
Wu Z, Zheng Z, Zhong W, Jiang Q, Cong M, Zhang H, Wang F, Liu Y, Hu H, Wang J.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The submersible Shinkai 6500 research cruises and the results (JAMSTEC Journal of Deep Sea Research Special Volume)

JAMSTEC Journal of Deep Sea Research special volume "Deep sea research in Subduction Zones, Spreading Centers and Backarc ...
Fujioka, Kantaro, Deep Sea Research Group   +1 more
core  

Depth for Underwater Acoustic Detection in Deep-Sea (>5000 m) Complex Marine Environments Based on the Bellhop Model. [PDF]

Sensors (Basel)
Sun X, Zhang S, Wang P.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Ammonia oxidation and recalcitrant carbon degradation fuel mixotrophic growth in the symbiont community of a deep-sea sponge. [PDF]

Microbiome
Garritano AN, J Hill L, Ribeiro B, Damasceno T, Medeiros L, Duarte G, L S Vilela C, Majzoub ME, Allen MA, Nappi J, S Peixoto R, Thomas T.   +11 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Global Deep Sea Exploration Goals: A representative approach to visually observing the deep seafloor. [PDF]

Sci Adv
Johannes KN, Poulton SE, Kennedy BRC, Bell KLC.   +3 more
europepmc   +1 more source