Results 171 to 180 of about 4,061,607 (254)

A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone. [PDF]

Nature
Peng X, Zhou P, Song X, Bianucci G, Du M, Collareta A, Gao Z, Xie T, Teng M, Leduc D, Mills S, Ta K, Li J, Wei T, Dasgupta S, Liu H, He Y, Xu W, Liu S, Zhang H.   +19 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

New γ-Unsaturated Lactone and Aliphatic Acid From the Deep-Sea-Derived Fungus Penicillium crustosum HDN17-68. [PDF]

Chem Biodivers
Yusawat N, Wang W, Deng X, Xu H, Ma C, Li D, Klaypradit W, Mookdasanit J, Zhang G.   +8 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A segmented computational method for deformation and dynamic characteristics analysis of deep-sea hydraulic valve. [PDF]

Sci Prog
Li X, Dong R, Xin C, Yao J, Yang S, Wang P, Ren Y.   +6 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Global distribution of deep-sea natural products shows environmental and phylogenetic undersampling with potential for biodiscovery. [PDF]

Sci Rep
Harris LM, Preet G, Desai R, Hasan AH, Vad J, Bribiesca-Contreras G, Astakala RV, Glover AG, Jaspars M, Copley J.   +9 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Genome-Wide 6mA Map Unveils Epigenetic Adaptation in Deep-Sea Limpet. [PDF]

Ecol Evol
Chen C, Liu J, Zhuang R, Ni K, Wang M, Li Y, Wang J, Wang S, Han W, Bao L.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source