Results 161 to 170 of about 1,292,419 (308)

Environmental Adaptation Strategies of Deep-Sea Fungi. [PDF]

J Fungi (Basel)
Leng S, Liu CH.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Crystallization Behavior of the Hydrogen Sulfide Hydrate Formed in Microcapillaries

ACS Omega, 2021
Jiyue Sun, I-Ming Chou, Lei Jiang, Juezhi Lin, Rui Sun   +4 more
doaj   +1 more source

Genome-Wide 6mA Map Unveils Epigenetic Adaptation in Deep-Sea Limpet. [PDF]

Ecol Evol
Chen C, Liu J, Zhuang R, Ni K, Wang M, Li Y, Wang J, Wang S, Han W, Bao L.   +9 more
europepmc   +1 more source

Deep sea mega-geomorphology: Progress and problems [PDF]

Historically, marine geologists have always worked with mega-scale morphology. This is a consequence both of the scale of the ocean basins and of the low resolution of the observational remote sensing tools available until very recently. In fact, studies
Bryan, W. B.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

New Compounds From the Deep-sea Sponge Mycale lingua. [PDF]

Chem Biodivers
Clark HP, Horsley D, Serpell-Stevens A, Horton T, Larsson AI, Oluwabusola ET, Ebel R, De Clippele LH, Jaspars M.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Corrigendum: N-terminus GTPase domain of the cytoskeleton protein FtsZ plays a critical role in its adaptation to high hydrostatic pressure

Frontiers in Microbiology
Xue-Hua Cui, Xue-Hua Cui, Yu-Chen Wei, Xue-Gong Li, Xue-Gong Li, Xiao-Qing Qi, Xiao-Qing Qi, Long-Fei Wu, Long-Fei Wu, Long-Fei Wu, Wei-Jia Zhang, Wei-Jia Zhang   +11 more
doaj   +1 more source

Deep-sea image dataset for organism detection. [PDF]

Data Brief
Nishio T, Kawae Y.
europepmc   +1 more source