Results 71 to 80 of about 103,225 (263)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Body force-based method for determining flow velocity of sea water artesian circulating system

Zhongguo Jianchuan Yanjiu, 2019
[Objectives]Establish a method capable of quickly calculating the flow velocity of an artesian circulating system,in order to optimize and compare multiple design schemes for key components of the sea water artesian circulating system.[Methods]Numerical ...
Chen Kang, Yao Zhichong, Zhou Endong, Xia Bin   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Deep-sea natural products

Natural Product Reports, 2008
This review covers the 390 novel marine natural products described to date from deep-water (>50 m) marine fauna, with details on the source organism, its depth and country of origin, along with any reported biological activity of the metabolites. Relevant synthetic studies on the deep-sea natural products have also been included.
openaire   +4 more sources

Deep pockets for deep seas [PDF]

Eos, Transactions American Geophysical Union, 1999
Peter Auster, a fisheries ecologist with the National Undersea Research Center in Connecticut, plans to assess degradation of the deep‐shelf seafloor from bottom trawling. Magnus Ngoile, an official with Tanzania's National Environmental Management Council, will work on building capacity of poor villagers to protect their coastline.
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Viral ecogenomics across oxic and anoxic zones of the Yongle Blue Hole

Environmental Microbiome
Background Deep ocean blue holes are characterized by distinct physicochemical gradients and complex biological processes, and Yongle Blue Hole (YBH) in the South China Sea (SCS) is the world’s deepest (301 m) underwater cavern with unique environmental ...
Ming Yang, Hong-Xi Zhang, Ying-Li Zhou, Ramganesh Selvarajan, Pei-Kuan Xu, Zhao-Ming Gao, Yong Wang   +6 more
doaj   +1 more source

Marine Sound Separation Algorithm Based on Time-Frequency Interleaved Attention and Integrated Filtering Module

水下无人系统学报
To address the problems of refined perception and discrimination of sound features caused by complex marine soundscapes and the variable characteristics of underwater target signals, this paper proposed a marine sound separation algorithm based on time ...
Yudi WANG, Mingzhong YANG, Lixin LIU
doaj   +1 more source

Deep sea in deep trouble? [PDF]

Current Biology, 2015
Ahead of the imminent start of the industrial exploitation of deep sea resources, an EU report finds that scientific knowledge and understanding of this environment and its ecosystems still fall short of what would be needed for a sustainable use.
openaire   +2 more sources