Results 81 to 90 of about 4,061,607 (254)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2020 The complete mitochondrial genome of the deep sea amphipod Eurythenes magellanicus was determined in this paper. This molecular was 14,988 bp in length, and contained the typical 13 protein coding genes (PCGs), 22 transfer RNAs (tRNAs), two ribosomal ...
Jun-yuan Li +3 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Carbon-silicon species are unlikely in subduction-zone fluids
Communications Earth & EnvironmentIn subduction zones, carbon-bearing fluids play a pivotal role in deep carbon cycling and global climate change. Given that Earth’s interior is dominated by silicates, the existence of aqueous carbon-silicon (C-Si) species is crucial for assessing the ...
Nanfei Cheng +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2018 A combination of stable isotopic measurements was used to study food web structure of Hupo Bank in East Sea (Sea of Japan), an important snow crab fishing ground.
민원기 +4 more
core
Check List of Deep Sea Fishes [PDF]
, 2007 Under the ASEAN-SEAFDEC program on the Deep Sea Fisheries Resources Exploration in the Southeast Asian Waters has been implemented since 2007. The main objectives are to support member countries for better understanding on the existing deep sea fisheries
Prommas, Ritthirong +2 more
core
Body force-based method for determining flow velocity of sea water artesian circulating system
Zhongguo Jianchuan Yanjiu, 2019 [Objectives]Establish a method capable of quickly calculating the flow velocity of an artesian circulating system,in order to optimize and compare multiple design schemes for key components of the sea water artesian circulating system.[Methods]Numerical ...
Chen Kang +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source