Results 71 to 80 of about 204,461 (310)

Adaptation strategies of iron-oxidizing bacteria Gallionella and Zetaproteobacteria crossing the marine–freshwater barrier

open access: yesmBio
Iron-oxidizing Betaproteobacteria and Zetaproteobacteria are generally associated with freshwater and marine environments, respectively. Despite repeated cross-environment observations of these taxa, there has been no focused exploration of the genomes ...
Petra Hribovšek   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Temporary expansion to shelf depths rather than an onshore-offshore trend: the shallow-water rise and demise of the modern deep-sea brittle star family Ophiacanthidae (Echinodermata: Ophiuroidea)

open access: yes, 2013
Hypotheses on the age and possible antiquity of the modern deep-sea fauna put forward to date almost all agree on the assumption that the deep-sea fauna is largely the result of colonisation from shallow-water environments. Here, the fossil record of the
Thuy, Ben, Ben Thuy
core   +1 more source

Contrasting responses to nutrient enrichment of prokaryotic communities collected from deep sea sites in the Southern Ocean [PDF]

open access: yes, 2013
Deep water samples (ca. 4,200 m) were taken from two hydrologically-similar sites around the Crozet islands with highly contrasting surface water productivities. Site M5 was characteristic of high productivity waters (high chlorophyll) whilst site M6 was
McCarthy, David   +15 more
core   +1 more source

Interactions in the Deep Sea

open access: yes, 2019
The deep–ocean floor extends over two thirds of the world’s surface, and is thus the largest benthic habitat on the planet. The myth of depauperate deep–sea communities was debunked in the 1960s by the pioneering work of Hessler and Sanders (Hessler and Sanders, 1967; Sanders and Hessler, 1969) with their newly developed epibenthic sled.
Allcock, A. Louise, Johnson, Mark P.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Home - About - Disclaimer - Privacy