Results 91 to 100 of about 2,623,398 (248)

Characteristics of performing continuous deep sedation until death in 2007 and 2013^{a b}.

, 2016
Characteristics of performing continuous deep sedation until death in 2007 and 2013a b.
Lenzo Robijn (2851322), Judith Rietjens (2851325), Joachim Cohen (793887), Luc Deliens (398588), Kenneth Chambaere (793886)   +4 more
core   +1 more source

Effect of high-flow nasal oxygen therapy on cardiac cycle efficiency in coronary artery disease patients undergoing endoscopy: study protocol for randomised controlled trial

BMJ Open
Introduction Patients with coronary artery disease (CAD) have diminished tolerance for gastrointestinal endoscopy procedures (upper/lower) performed under deep sedation, resulting in increased incidence rates of hypotension and myocardial ischaemia among
Sheng Wang, Tingting Ma, Fang Xie, Mu Jin, Xiaorui Zhou   +4 more
doaj   +1 more source

Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (SED-CARE): A protocol for a randomized clinical trial. [PDF]

Acta Anaesthesiol Scand
Background: Sedation is often provided to resuscitated out-of-hospital cardiac arrest (OHCA) patients to tolerate post-cardiac arrest care, including temperature management.
Ceric A, Dankiewicz J, Hästbacka J, Young P, Niemelä VH, Bass F, Skrifvars MB, Hammond N, Saxena M, Levin H, Lilja G, Moseby-Knappe M, Tiainen M, Reinikainen M, Holgersson J, Kamp CB, Wise MP, McGuigan PJ, White J, Sweet K, Keeble TR, Glover G, Hopkins P, Remmington C, Cole JM, Gorgoraptis N, Pogson DG, Jackson P, Düring J, Lybeck A, Johnsson J, Unden J, Lundin A, Kåhlin J, Grip J, Lotman EM, Romundstad L, Seidel P, Stammet P, Graf T, Mengel A, Leithner C, Nee J, Druwé P, Ameloot K, Nichol A, Haenggi M, Hilty MP, Iten M, Schrag C, Nafi M, Joannidis M, Robba C, Pellis T, Belohlavek J, Rob D, Arabi YM, Buabbas S, Yew Woon C, Aneman A, Stewart A, Reade M, Delcourt C, Delaney A, Ramanan M, Venkatesh B, Navarra L, Crichton B, Williams A, Knight D, Tirkkonen J, Oksanen T, Kaakinen T, Bendel S, Friberg H, Cronberg T, Jakobsen JC, Nielsen N.   +77 more
europepmc   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Deep sedation for Catheter Ablation of atrial fibrillation: A prospective study in 650 consecutive patients

, 2011
Introduction: Catheter ablation of atrial fibrillation (AF) is a highly invasive and relatively long-lasting procedure with specific requirements for patient sedation. The feasibility and safety of deep sedation is described in a prospective study of 650
Kottkamp, H., Arya, A., Koch, J., Varounis, C., Sommer, P., Piorkowski, C., Hindricks, G., Eitel, C., Gaspar, T., Dagres, N., Müller, K., Siedziako, A., Anastasiou-Nana, M.   +12 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quantitative Pupillometry to Monitor Deep Sedation In Mechanically Ventilated Critically Ill Patients

, 2021
Oversedation and occurrence of negative outcomes Sedation is widely used in the intensive care unit (ICU) setting to tolerate invasive procedures and ensure comfort to the patient (1,2) Only a limited number of ICU patients have a condition requiring ...
GOBET, F.
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Changes in a raw EEG trace of dexmedetomidine sedation and propofol sedation from channel Fz.

, 2018
WA, wakefulness; MS, moderate sedation; DS, deep sedation; RS, recovery state (RS). During MS and DS, the EEG differences between the two agents are obvious.
Fang Ji (41541), Shiyue Sun (645694), Xu Cui (261214), Chuxiong Pan (4892107), Chunhua Xi (3852952), Tianzuo Li (794338)   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source