Results 81 to 90 of about 43,842 (295)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Palliative sedation – revised recommendations [PDF]

Palliative sedation is defined as the monitored use of medications intended to induce a state of decreased or absent awareness (unconsciousness) to relieve the burden of otherwise intractable suffering in a manner ethically acceptable to the patient ...
Marta Mazzoli, Steffen Eychmüller, Eychmüller, S., Gaertner, Jan, Josiane Pralong, Mazzoli, M., Martyna Tomczyk, Beauverd, Michel, Gaertner, J., Beauverd, M., Pralong, J., Jan Gaertner, Mazzoli, Marta, Tomczyk, M., Pralong, Josiane, Michel Beauverd, Eychmüller, Steffen, Tomczyk, Martyna   +17 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Propofol-based deep sedation for endoscopic retrograde cholangiopancreatography procedure in sick elderly patients in a developing country

, 2011
Somchai Amornyotin1,3, Udom Kachintorn2,3, Wiyada Chalayonnawin1,3, Siriporn Kongphlay1,31Department of Anesthesiology, 2Department of Medicine, 3Siriraj GI Endoscopy Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok ...
Chalayonnawin W, Kongphlay S, Amornyotin S, Kachintorn U   +3 more
core  

Deciding about continuous deep sedation: physicians' perspectives A focus group study

, 2009
Although guidelines restrict the use of continuous deep sedation to patients with refractory physical symptoms and a short life-expectancy, its use is not always restricted to these conditions. A focus group study of physicians was conducted to gain more
Rietjens, Judith, van der Heide, Agnes; id_orcid, Maas, Paul, van der Heide, Agnes, Buiting, Hilde, van Delden, JJM, Pasman, HRW (Roeline)   +6 more
core   +1 more source

Office-Based Deep Sedation for Pediatric Ophthalmologic Procedures Using a Sedation Service Model [PDF]

, 2012
Aims. (1) To assess the efficacy and safety of pediatric office-based sedation for ophthalmologic procedures using a pediatric sedation service model.
David Wheeler, Matthew Tomlinson, Kirk Lalwani, Jeffrey Koh   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Continuous deep sedation for patients nearing death in the Netherlands: descriptive study [PDF]

, 2008
Objectives To study the practice of continuous deep sedation in 2005 in the Netherlands and compare it with findings from 2001. Design Questionnaire study about random samples of deaths reported to a central death registry in 2005 and 2001. Setting
Rietjens, J.A.C., Maas, Paul, van Delden, J, van Delden, J.J.H., van Delden, Johannes, Delden, J.J.M. (Hans) van, Onwuteaka-Philipsen, B.D. (Bregje), van der Heide, A., Maas, P.J. (Paul) van der, Rietjens, J.A.C. (Judith), Buiting, H.M. (Hilde), Rietjens, Judith, van der Heide, Agnes; id_orcid, van der Maas, Paul, Onwuteaka-Philipsen, B.D., van der Heide, Agnes, Buiting, Hilde, van der Heide, Agens, Onwuteaka-Philipsen, B, Heide, A. (Agnes) van der, Buiting, H., Onwuteaka-Philipsen, Bregie, Maas, P.   +22 more
core   +1 more source

Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort

Critical Care, 2019
Objectives We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a resource-limited setting.
Romina E. Aragón, Alvaro Proaño, Nicole Mongilardi, Aldo de Ferrari, Phabiola Herrera, Rollin Roldan, Enrique Paz, Amador A. Jaymez, Eduardo Chirinos, Jose Portugal, Rocio Quispe, Roy G. Brower, William Checkley   +12 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source