Results 121 to 130 of about 43,842 (295)

Safety and efficacy of a cardiologist-only approach to deep sedation for electrical cardioversion

, 2019
Electrical cardioversion is still the preferred method to restore sinus rhythm in patients with atrial fibrillation. The main disadvantage is that electrical cardioversion requires deep sedation, generally administered by anaesthesiologists, for safety ...
Giovanni Morani, Bolzan, Bruna, Flavio L. Ribichini, Borio, Gianluca, Morani, Giovanni, Bruna Bolzan, Gianluca Borio, Ribichini, Flavio L   +7 more
core   +1 more source

Continuous Deep Sedation in the Newborn: Knowledge and Need [PDF]

Neonatology, 2021
Thor Willy Ruud Hansen, Dominic J.C. Wilkinson   +1 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessing respiratory complications in patients with obesity and obstructive sleep apnea undergoing a screening colonoscopy with moderate and deep sedation

, 2020
Introduction: Millions of screening colonoscopies are performed annually which means there is a substantial health cost for insurances. There has been more utilization of deep sedation requiring costly anesthesia services compared to moderate sedation ...
Bhatti, Simran K, Kaur, Randeep, Nimri, Faisal M, Kutait, Anas, Columbus Morales, Ivan M, Ashraf, Taha   +5 more
core  

Clinical Impact of Local Anesthesia on Sedation Stability and Propofol Dosage in Pediatric Dental Sedation

European Annals of Dental Sciences
Background: Local anesthesia (LA) is often preferred for stabilization of vital signs, depth of anesthesia and pain control in dental restorations but the efficacy of LA administration during deep sedation is controversial.Aim ...
Merve Hayriye Kocaoglu, Çağıl Vural, Betül Büşra Ursavaş   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Moderate and deep nurse-administered propofol sedation is safe

, 2015
INTRODUCTION: Non-anaesthesiologist-administered propofol sedation (NAPS/NAAP) is increasingly used in many countries. Most regimens aim for light or moderate sedation. Little evidence on safety of deep NAPS sedation is available.
Jensen, Jeppe Thue, Møller, Ann, Konge, Lars, Vilmann, Peter, Hornslet, Pernille   +4 more
core  

Post-Discharge Events Occurring after Dental Treatment under Deep Sedation in Pediatric Patients

, 2017
Purpose: Deep sedation is often required in dentistry for treating children with uncooperative behavior. We assessed immediate post-sedation events during the first 24 hours after dental treatment under deep sedation in children, and examined ...
Jacob Efrat, David Gozal, Esti Davidovich, Liron Meltzer, Diana Ram   +4 more
core   +1 more source

Procedural sedation analgesia

Saudi Journal of Anaesthesia, 2010
The number of noninvasive and minimally invasive procedures performed outside of the operating room has grown exponentially over the last several decades.
Sheta Saad
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source