Results 141 to 150 of about 2,623,398 (248)

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Sedation in the intensive care setting

, 2012
Christopher G Hughes, Stuart McGrane, Pratik P PandharipandeVanderbilt University School of Medicine, Nashville, TN, USAAbstract: Critically ill patients are routinely provided analgesia and sedation to prevent pain and anxiety, permit invasive ...
Pandharipande PP, McGrane S, Hughes CG
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Intensive care unit sedation: nurses monitoring techniques

reservedDescrizione delle varie tecniche di monitoraggio in relazione alle problematiche conseguenti alla sedazione in terapia intensiva, con analisi delle cause principali di scompenso nel paziente.Description of the various monitoring techniques in ...
SATTIN, ALESSIA
core  

Analgosedation for catheter ablation in deep sedation: comparison between cryoballoon and pulsed field ablation. [PDF]

Europace
Nies M, Rottner L, Unruh I, Obergassel J, Rieß J, Schenker N, Ismaili D, Benesch Vidal ML, Christmann D, Skibowski J, Scharlemann L, Otto C, Kany S, Lemoine MD, Reißmann B, Ouyang F, Kirchhof P, Metzner A, Rillig A.   +18 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Technical success and adverse event rates after endoscopic retrograde cholangiopancreatography using deep sedation with propofol [PDF]

BACKGROUND: With the increasing complexity and prolonged duration of endoscopic retrograde cholangiopancreatography (ERCP) procedures, sedation shifted from conscious sedation with benzodiazepines to deep sedation with propofol. We assessed the technical
Didden, Paul, Vleggaar, Frank P, Kastelijn, Janine B, van den Berg, A Merel, Talwar, Raju, Koks, Marije S, van Erpecum, Karel J, Marsman, Marije, Moons, Leon M G, Infection & Immunity, Medische staf Anesthesiologie, CTC, Circulatory Health, MS MDL 1, Cancer   +14 more
core  

Vagal Response and Cough Reflex During Atrial Fibrillation Ablation Under Deep Sedation: A Comparison Across Pulsed Field Ablation Systems. [PDF]

J Arrhythm
Saito J, Kuroki K, Goto T, Asahina C, Sudo K, Sato A.   +5 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

PFA Under Deep Sedation and Non-Invasive Monitoring in Atrial Fibrillation Patients With Obstructive Sleep Apnea. [PDF]

Pacing Clin Electrophysiol
Leftheriotis D, Papathanasiou KA, Karamanolis E, Vlachodiamanti A, Stamatopoulou E, Polikandrioti M, Flevari P.   +6 more
europepmc   +1 more source