Results 81 to 90 of about 72,658 (304)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Maxillary nerve block: A comparison between the greater palatine canal and high tuberosity approaches. [PDF]

, 2018
Aim: Analgesia and anxiolysis during dental procedures are important for dental care and patient compliance. This study aims to compare two classical maxillary nerve block (MNB) techniques: the greater palatine canal (GPC) and the high tuberosity (HT ...
Bacci, C, Bartorelli, Lmg, Ferrario, S, Grossi, Gb, Menozzi, G, Sivolella, S, Zanette, G.   +6 more
core  

The Odyssey of Dental Anxiety: From Prehistory to the Present. A Narrative Review [PDF]

, 2017
Dental anxiety (DA) can be considered as a universal phenomenon with a high prevalence worldwide; DA and pain are also the main causes for medical emergencies in the dental office, so their prevention is an essential part of patient safety and overall ...
Abrahamsson, Abramiuk, Aitken, Ajram, Akers, Aldhouse-Green, Andrews-Hanna, Apicella, Araújo, Armfield, Arsati, Aydede, Balick, Batelaan, Bednarik, Benarroch, Berggren, Berggren, Bernard, Bernardini, Bertolini, Biondich, Bonica, Bourguignon, Boyd, Bracken, Bruhn, Brunton, Buckner, Campos, Campos, Cannon, Cannon, Cannon, Casiglia, Chambiras, Chicka, Collado, Colloca, Cooke, Coppa, Corah, Corah, Coriat, Cosmacini, Cross, Cunha, Dawson, de Jongh, De Lumley, De Mello, Deeley, Demertzi, Derbyshire, Dettwyler, Devereux, Di Marzo, Dobkin de Rios, Dobkin de Rios, Dobkin de Rios, Donald, Dunn, Eaton, Edelstein, El-Seedi, Eli, Eli, Eliade, Engel, Etkin, Eycleshimer, Facco, Facco, Facco, Facco, Facco, Facco, Facco, Facco, Facco, Facco, Facco, Facco, Facco, Fairley, Farb, Faymonville, Filimon, Forgione, Freeman, Friedman, Friedman, Friedman, Friedman, Gabora, Ganon-Elazar, Garofoli, Gatchel, Gosso, Goulding, Griffiths, Guerra-Doce, Gutmann, Hardy, Hardy, Hartogsohn, Harwood, Haugejorden, Hehmeyer, Helgason, Henshilwood, Hill, Hill, Huffman, Huffman, Huffman, Huffmant, Humphrey, Humphris, Humphris, Iacoboni, Irish, Jones, Jung, Keller, Kessler, Kingsley, Kline, Krippner, Kuhn, Kurzweil, Kvale, Laland, Lalueza-Fox, Laughlin, Leary, Lee, Levin, Lewin, Lewis-Williams, Lewis-Williams, Lewis-Williams, Liddell, Locker, Locker, Lordkipanidze, Machen, MacLean, Malamed, Manani, Mancuso, Mantegazza, Marcuse, Matsuura, McKenna, Mellars, Merskey, Minagar, Moore, Morgan, Moss, Moss, Moss, Navet, Newman, Newton, Newton, Nichols, Niwa, O'Sullivan, Ott, Oxenham, Oxilia, Pandit, Panksepp, Parkin, Parravicini, Porges, Porges, Porges, Potts, Quintana, Rainville, Rainville, Rainville, Ratsch, Relman, Renfrew, Reuter, Richerson, Rizzolatti, Roberts, Roder, Rodriguez, Russo, Samorini, Samorini, Samorini, Schultes, Schultes, Severino, Shoben, Sommer, Spikins, Springer, Stein, Stephenson, Sterelny, Sterelny, Stolberg, Strubelt, Taneja, Tarlow, Tilley, Trinkaus, Van Pool, Vanhaudenhuyse, Vogel, Von Bibra, Warwick, Wasson, West, Wilson, Wiltshire, Winkelman, Wrangham, Yagiela, Zanette, Zias, Zias, Zinberg, Zorich   +231 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Comparison of Moderate Oral Sedation Drug Regimens for Pediatric Dental Treatment: A Pilot Study [PDF]

, 2017
Purpose: Compare moderate oral sedation of pediatric patients using Hydroxyzine and Meperidine with either Diazepam or Midazolam in management of pediatric dental patients. Methods: Randomized, double-blind, crossover pilot study of patients 3 to 7 years
Parikh, Ojas A
core   +1 more source

Arrhythmia induction using isoproterenol or epinephrine during electrophysiology study for supraventricular tachycardia [PDF]

, 2018
Background Electrophysiology study (EPS) is an important part of the diagnosis and workup for supraventricular tachycardia (SVT). Provocative medications are used to induce arrhythmias, when they are not inducible at baseline. The most common medication
Padanilam, Benzy J., Patel, Jyoti Kandlikar, Patel, Parin J., Prystowsky, Eric N., Segar, Rachel   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Anesthetic management in atrial fibrillation ablation procedure: Adding non-invasive ventilation to deep sedation

Indian Pacing and Electrophysiology Journal, 2015
Anesthetic management of patients undergoing pulmonary vein isolation for atrial fibrillation has specific requirements. The feasibility of non-invasive ventilation (NIV) added to deep sedation procedure was evaluated.
Francesco Sbrana, Andrea Ripoli, Bruno Formichi   +2 more
doaj   +1 more source

The use of intra-articular aneshesia as a diagnostic tool in canine lameness [PDF]

, 2012
Lameness in dogs may be difficult to localize because of mild pathologic changes or inconclusive clinical findings. Intra-articular anesthesia is proposed as a diagnostic method to localize the source of lameness.
Mosselmans, Lynn, Samoy, Yves, Van Ryssen, Bernadette, Van Vynckt, Delphine, Verhoeven, Geert, Verschooten, Francis   +5 more
core   +1 more source

Management of paediatric procedure-related cancer pain

, 1999
Paediatric malignancy is not always painful in its own right; however, young patients with cancer undergo numerous painful procedures for diagnosis, therapy and supportive care, including lumbar puncture, bone marrow aspiration and biopsy.
Liossi, C.
core   +1 more source