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Integrated targeted deep sequencing reveals unique tissue-of-origin and donor-derived cell-free DNA signatures in organ transplant recipients

Kueng N, Sandberg F, Sidler D, Banz V, Berzigotti A, Ng CKY, Largiadèr CR, Amstutz U.   +7 more
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Deep Sequencing in Cancer Research

Japanese Journal of Clinical Oncology, 2012
Cancer is caused by alterations in the cellular genome including single-nucleotide variations, small insertions and deletions (indels), copy number changes and other structural variations and, as such, their detection in a comprehensive manner is of critical importance for fully understanding cancer pathogenesis, improvement of diagnosis as well as the
Kenichi, Yoshida, Masashi, Sanada, Seishi, Ogawa   +2 more
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Deep Sequencing

Science Translational Medicine, 2009
Genes that cause rare disorders are uncovered by deep resequencing of protein-coding regions.
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Deep sequencing of myxoinflammatory fibroblastic sarcoma

Genes, Chromosomes and Cancer, 2020
AbstractMyxoinflammatory fibroblastic sarcoma (MIFS) has recurrent genetic features in the form of a translocation t(1;10)(p22‐31;q24‐25),BRAFgene fusions, and/or an amplicon in 3p11‐12 including theVGLL3gene. The breakpoints on chromosomes 1 and 10 in the t(1;10) cluster in or near theTGFBR3andOGAgenes, respectively. We here used a combination of deep
Elsa Arbajian, Jakob Hofvander, Linda Magnusson, Fredrik Mertens   +3 more
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Deep sequencing blood transcriptomes

Blood, 2014
In this issue of Blood , five satellite manuscripts from the Functional Annotation of the Mammalian Genome (FANTOM5) consortium show the power of deep transcriptome sequencing to identify genes, promoters, and enhancers specific to different hematopoietic subpopulations.[1][1][⇓][2][⇓][3 ...
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RNA structure from deep sequencing

Nature Biotechnology, 2015
A method to identify interacting regions in a folded RNA is a step toward solving RNA structures from sequencing data.
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Deep sequencing reveals novel Set7 networks

Cellular and Molecular Life Sciences, 2014
Methyl-dependent regulation of transcription has expanded from a traditional focus on histones to encompass transcription factor modulation. While the Set7 lysine methyltransferase is associated with pro-inflammatory gene expression in vascular endothelial cells, genome-wide regulatory roles remain to be investigated.
Samuel T, Keating, Mark, Ziemann, Jun, Okabe, Abdul Waheed, Khan, Aneta, Balcerczyk, Assam, El-Osta   +5 more
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Deep Sequencing Approaches to Antibody Discovery

Current Drug Discovery Technologies, 2014
Antibodies have become one of the dominant therapeutic platforms due to their safety, specificity, and efficacy. Owing to their massive potential diversity intrinsic to their structure, the number of possible different molecules that could be generated and analyzed from natural or synthetic systems is almost limitless.
Michael F, Naso, Jin, Lu, Tadas, Panavas
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Footprints by deep sequencing

Nature Methods, 2009
Deep sequencing of DNase I–treated yeast DNA yields genome-wide information on chromatin transitions as well as protein binding in these regions.
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DNA Replication Profiling Using Deep Sequencing

2017
Profiling of DNA replication during progression through S phase allows a quantitative snap-shot of replication origin usage and DNA replication fork progression. We present a method for using deep sequencing data to profile DNA replication in S. cerevisiae.
Xanita, Saayman, Cristina, Ramos-Pérez, Grant W, Brown   +2 more
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