Results 111 to 120 of about 472,930 (267)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Could Narrow Bipolar Events Serve as a Distinct Lightning Proxy for Revealing Overshooting Thunderclouds Development?

Geophysical Research Letters
Narrow bipolar events (NBEs) are often generated in overshooting thunderclouds (OT) penetrating the stratosphere. However, how and under what conditions OT produces such discharges remains unclear.
Baojun Wu, Feifan Liu, Baoyou Zhu, Gaopeng Lu, Wenhao Xu, Ming Luo, Weitao Lyu, Jiuhou Lei   +7 more
doaj   +1 more source

Combined optical line-of-sight and crosslink radiometric navigation for distributed deep-space systems. [PDF]

Sci Rep, 2023
Casini S, Turan E, Cervone A, Monna B, Visser P.   +4 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Direct Observations of Large‐Scale Wave Structure and Post‐Sunset Rise of the Ionosphere in the Generation of Equatorial Spread F

Geophysical Research Letters
Large‐scale wave structure (LSWS) and the post‐sunset rise (PSSR) are two key factors in the generation of equatorial spread F (ESF). In this study, we reported continuous and direct observations of LSWS and PSSR and their effects on seeding ESF by Sanya
Qi Jiang, Jiuhou Lei, Xinan Yue, Fuqing Huang, Rong Xia, Tong Dang, Xiaoli Luan   +6 more
doaj   +1 more source

Effects of neutron radiation generated in deep space-like environments on food resources. [PDF]

Sci Rep, 2023
Hatsuda M, Kawasaki H, Shigenaga A, Taketani A, Takanashi T, Wakabayashi Y, Otake Y, Kamata Y, Ichinose A, Nishioka H, Kimura H, Koganei Y, Komoriya S, Sakai M, Hamano Y, Yoshida M, Yamakura F.   +16 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A Substorm‐Dependent Negative Limit of Non‐Eclipse Surface Charging of a Chinese Geosynchronous Satellite

Space Weather
Surface charging is one of the most common causes of spacecraft anomalies. When and to what potential the spacecraft is charged are two important questions in space weather.
Zhiyi Fu, Zhenpeng Su, Bin Miao, Zhiyong Wu, Yiren Li, Kai Liu, Xu Shan, Yuming Wang   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source