Results 111 to 120 of about 471,556 (267)

Celestial Bodies Far-Range Detection with Deep-Space CubeSats. [PDF]

Sensors (Basel), 2023
Franzese V, Topputo F.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Combined optical line-of-sight and crosslink radiometric navigation for distributed deep-space systems. [PDF]

Sci Rep, 2023
Casini S, Turan E, Cervone A, Monna B, Visser P.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Could Narrow Bipolar Events Serve as a Distinct Lightning Proxy for Revealing Overshooting Thunderclouds Development?

Geophysical Research Letters
Narrow bipolar events (NBEs) are often generated in overshooting thunderclouds (OT) penetrating the stratosphere. However, how and under what conditions OT produces such discharges remains unclear.
Baojun Wu, Feifan Liu, Baoyou Zhu, Gaopeng Lu, Wenhao Xu, Ming Luo, Weitao Lyu, Jiuhou Lei   +7 more
doaj   +1 more source

Effects of neutron radiation generated in deep space-like environments on food resources. [PDF]

Sci Rep, 2023
Hatsuda M, Kawasaki H, Shigenaga A, Taketani A, Takanashi T, Wakabayashi Y, Otake Y, Kamata Y, Ichinose A, Nishioka H, Kimura H, Koganei Y, Komoriya S, Sakai M, Hamano Y, Yoshida M, Yamakura F.   +16 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A Fully Connected Neural Network for Fast Estimation of Quasi‐Linear Diffusion Coefficients

Space Weather
Wave–particle interactions are a fundamental driver of electron radiation belt dynamics. Quantifying their effects through quasi‐linear theory requires diffusion coefficients, but their direct evaluation involves nested integrations and is ...
Mengli Tan, Yifan Wu, Zeyu An, Peng Peng, Xin Tao   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source