Results 101 to 110 of about 472,930 (267)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Latitudinal Discrepancy Between Thermospheric Density and Temperature Associated With Neutral Composition Effect

Geophysical Research Letters
In this study, multi‐source thermospheric observations and TIEGCM simulations were used to explore the latitudinal variations of thermospheric temperature and total mass density at equinoxes.
Zhongli Li, Xiaoli Luan, Jiuhou Lei, Dexin Ren   +3 more
doaj   +1 more source

Evaluation of deep space exploration risks and mitigations against radiation and microgravity. [PDF]

Front Nucl Med, 2023
Dobney W, Mols L, Mistry D, Tabury K, Baselet B, Baatout S.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Existence of Electrostatic Ion Cyclotron Waves in a Laboratory Created E Region Ionospheric‐Like Plasma

Geophysical Research Letters
Molecular ions are relatively cold in the E region ionosphere; however, they can upwell to the magnetosphere during geomagnetically active times. Resonance between electrostatic ion cyclotron (EIC) waves is a potential pathway to energize molecular ions.
Yu Liu, Rong Jin, Minchi Li, Wenlong Huang, Kexin Huang, Junnan Jiang, Pengcheng Yu, Jiuhou Lei   +7 more
doaj   +1 more source

Nourishing the brain on deep space missions: nutritional psychiatry in promoting resilience. [PDF]

Front Neural Circuits, 2023
Pathare NN, Fayet-Moore F, Fogarty JA, Jacka FN, Strandwitz P, Strangman GE, Donoviel DB.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Celestial Bodies Far-Range Detection with Deep-Space CubeSats. [PDF]

Sensors (Basel), 2023
Franzese V, Topputo F.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Deep Learning in Cinematic Space

This short essay is an attempt to question the power we attribute to technology by drawing potentially new connections between the use of Artificial Intelligences in Stanley Kubrick’s 2001, A Space Odyssey and contemporary usages of artificial intelligences like ‘The Innovation Engine’. Kubrick gave us a warning. The subject of artificial intelligences,
openaire   +1 more source