Results 81 to 90 of about 472,930 (267)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

Earth and Planetary Physics
The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly understood. In this article, we present an electron current layer detected at the edge of the magnetotail plasma sheet.
ChenChen Zhan, RongSheng Wang, QuanMing Lu, San Lu, XinMin Li   +4 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Were Gravity Waves or Lamb Waves Responsible for the Large‐Scale Thermospheric Response to the Tonga Eruption?

AGU Advances
The extraordinary eruption of the Tonga volcano on 15 January 2022 lofted material to heights exceeding 50 km, marking the highest observed since the satellite era.
Ruoxi Li, Jiuhou Lei, Shun‐Rong Zhang, Feifan Liu, Xuetao Chen, Xiaoli Luan, Xing Meng   +6 more
doaj   +1 more source

Formation of Lunar Swirls: Implication from Derived Nanophase Iron Abundance

Remote Sensing
Lunar swirls are enigmatic features on the Moon’s surface, and their formation remains debated. Previous studies suggest that the distinctive spectral characteristics of lunar swirls result from the asymmetric space weathering between their bright ...
Wanqi Zhao, Xin Ren, Bin Liu, Yao Xiao, Dawei Liu   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Space weather and deep space communications

Space Weather, 2007
While Pioneer 11 and Galileo are two deep space missions that experienced radio communication disruptions due to space weather, the success of a mission like Solar Probe, whose goal is to fly by the Sun within a few solar radii of its surface, may depend critically on space weather.
openaire   +1 more source