Results 71 to 80 of about 472,930 (267)

Seismic visibility of carbonated subducted oceanic crust in the lower mantle

Communications Earth & Environment
Seismological studies have previously detected abundant scatterers in the lower mantle, potentially linked to long-term slab subduction, and petrology studies suggest carbonates can be sequestrated within the oceanic crust and transported into the lower ...
Yajie Zhao, Xin Deng, Wenzhong Wang, Zhongqing Wu, Ye Yuan   +4 more
doaj   +1 more source

Energy Conversion Associated with Intermittent Currents in the Magnetosheath Downstream of the Quasi-Parallel Shock

Magnetochemistry
Using the data from the Magnetospheric Multiscale (MMS) mission, we studied the energy conversion between electromagnetic fields and particles (ions and electrons) in a spacecraft rest frame inside a turbulent magnetosheath downstream of the quasi ...
Xinmin Li, Rongsheng Wang, San Lu, Ao Guo, Zhijian Zhang   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Development and mechanical behavior of ice-cemented Martian Regolith Simulant (TJ-MRS01) for future mars sample-return engineering studies

Earth, Planets and Space
Ice-cemented regolith exists on Mars and could significantly influence surface mechanical behavior, affecting drilling, mobility, and sample acquisition strategies.
Siji Sanlang, Kaihan Xu, Chao Wang, Xiaohua Tong, Huan Xie, Yongjiu Feng, Xiong Xu, Yusheng Xu   +7 more
doaj   +1 more source

Ion and electron motions in the outer electron diffusion region of collisionless magnetic reconnection

Earth and Planetary Physics
Two-dimensional particle-in-cell simulations are performed to study the coupling between ion and electron motions in collisionless magnetic reconnection. The electron diffusion region (EDR), where the electron motions are demagnetized, is found to have a
Cong Chang, QuanMing Lu, San Lu, Kai Huang, RongSheng Wang   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Retrieving water ice abundance in representative regions of the Moon’s South Pole using topography corrected SELENE MI images

Geoscience Letters
Previous studies have reported the existence of water ice in the lunar polar regions, but estimations of water ice using different methods vary in certainty, precision, location, and abundance.
Xindi Long, Chao Wang, Siji Sanlang, Yongjiu Feng, Xiong Xu, Huan Xie, Xiaohua Tong   +6 more
doaj   +1 more source

Numerical Simulations of the Lunar Penetrating Radar and Investigations of the Geological Structures of the Lunar Regolith Layer at the Chang’E 3 Landing Site

International Journal of Antennas and Propagation, 2017
In the process of lunar exploration, and specifically when studying lunar surface structure and thickness, the established lunar regolith model is usually a uniform and ideal structural model, which is not well-suited to describe the real structure of ...
Chunyu Ding, Yan Su, Shuguo Xing, Shun Dai, Yuan Xiao, Jianqing Feng, Danqing Liu, Chunlai Li   +7 more
doaj   +1 more source