Results 51 to 60 of about 9,754 (259)

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Evaluation Method of Roof Damage Degree and a Case Study in Maoping Lead-Zinc Mine, Yunnan

Shock and Vibration, 2022
With the continuous increase in the mining depth of underground mineral resources, the geological conditions encountered in mining have become more complex.
Jun Yang, Linke Qiao, Zhixiu Wang, Han Wang   +3 more
doaj   +1 more source

Femtosecond‐Laser‐Induced Physical Unclonable Random Maze Structure for Storage‐Free Encryption

Advanced Science, EarlyView.
Femtosecond‐laser‐induced gold random maze structures serve as multimodal physical unclonable functions for storage‐free encryption. Their stochastic optical, electrical, and Raman responses are generated by plasmon‐assisted Marangoni formation and converted into AES‐compatible keys without permanent secret‐key storage, offering a portable route toward
Shiru Jiang, Hongliang Li, Shengjie Ma, Sang‐Shin Lee, Lei Wang, Mengyun Hu, Heping Zeng   +6 more
wiley   +1 more source

The Layout of the Combustion Cavity and the Fracture Evolution of the Overlying Rock during the Process of Underground Coal Gasification

Geofluids, 2022
Based on the thermodynamic and elastodynamic theories, the controlling equation of temperature-stress coupling action on rocks containing random damage units is established by combining the Mogi-Coulomb damage criterion.
Zhaolin Li, Lianguo Wang, Bo Ren, Ke Ding   +3 more
doaj   +1 more source

Research of high pre-stress NPR support technology in deep shaft roadway engineering

矿业科学学报, 2023
Deep coal resources are the crucial backup for China's energy security in the future. However, large deformation and instability of rock mass in deep roadway engineering still poses serious problems in the deep "three high and one complex" geomechanical ...
Sun Xiaoming, Zhang Yong, He Manchao, Yang Jinkun   +3 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Seismic Behavior of Qinghai-Tibetan Railway Embankment in Permafrost Regions: A Case Study

Shock and Vibration, 2023
The temperature is a critical factor that determines the unfrozen water content and ice content in the frozen soil. In view of mechanical properties of the frozen soil depend on the volume of components of the four-phase systems, thus the temperature has
Tuo Chen, Jianzhou Wang, Bo Wang
doaj   +1 more source

Heat extraction efficiency in deep geothermal energy mining and implications for EGS-E

工程科学学报, 2022
Geothermal energy has recently attracted substantial attention due to its abundant reserve, cleanness, and sustainability. Geothermal reservoirs can be stimulated via different approaches/techniques that lead to different heat extraction efficiencies and
Ying-chun LI, Wen-ming SUN, Fang-chao KANG, Chun-an TANG   +3 more
doaj   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

A Global Methane Observation System to Reduce Uncertainty for Anthropogenic and Natural Sources and Sinks for Detecting and Attributing Climate Feedbacks

Advanced Science, EarlyView.
Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais, S. Peng, J. Chang, F. Li, Q. Zhu, K. Yuan, G. Hugelius, H. Li, Y. Cai, F. Chevallier, K. Tibrewal, E. A. Kort, K. Arndt, J. Watts, B. Buma, N. Besic, P. I. Palmer, H. Cadillo‐Quiroz, E. Euskirchen, M. J. Gondwe, A. Hoyt, R. Jackson, S. Malone, D. Monteverde, S. Natali, M. Ramonet, C. Rey‐Sanchez, L. B. Sagang, E. A. G. Schuur, R. Vargas, R. Varner, Z. Zhang, B. Poulter   +32 more
wiley   +1 more source