Results 51 to 60 of about 112,794 (257)

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Predicting deep venous thrombosis in pregnancy: external validation of the LEFT clinical prediction rule

Haematologica, 2013
The assessment of clinical probability represents an important step in the diagnostic strategy of patients with suspected deep vein thrombosis. The recently derived LEFt clinical prediction rule for pregnant women combines three variables: symptoms in ...
Marc Righini, Christelle Jobic, Françoise Boehlen, Jean Broussaud, François Becker, Morgan Jaffrelot, Marc Blondon, Bruno Guias, Grégoire Le Gal, the EDVIGE study group   +9 more
doaj   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Systemic thrombolysis in the upper extremity deep vein thrombosis

ARYA Atherosclerosis, 2011
Almost 4% of all patients with venous thrombosis have upper extremity deep vein thrombosis(UEDVT) and the incidence of UEDVT increases over time.
Roxana Sadeghi, Morteza Safi
doaj  

Deep Vein Thrombosis, Pulmonary Embolism and Related Factors in Patients with Traumatic Brain Injury

پزشکی بالینی ابن سینا, 2022
Background and Objective:Deep vein thrombosis and pulmonary embolism are fatal problems following brain trauma that, if left untreated, can dramatically increase mortality.
Fahimeh Esmaeili, Mshhood Aghajanloo, Amir Shams, Sajjad Abdolmalaki   +3 more
doaj  

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Thrombose e hemostase protocolos na prática clínica.

Acta Médica Portuguesa, 1994
We established several protocols: -analytic pre-operative tests; -analytic tests in pre-thrombotic states; -prophylaxis in deep vein thrombosis with LMW heparin; -treatment of deep vein thrombosis with LMW heparin; -oral anticoagulant supervision ...
F F Crespo
doaj   +1 more source

The Case of an 18‐Year‐Old Female With Persistent Vague Pain in the Top of the Occiput

Annals of Clinical and Translational Neurology, EarlyView.
Jianping Zhong, Binglin Lai
wiley   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

A machine learning-based predictive model for the occurrence of lower extremity deep vein thrombosis after laparoscopic surgery in abdominal surgery

Frontiers in Surgery
Background & aimsDeep vein thrombosis, a common complication after laparoscopic surgery, can negatively affect patients' limb motor function and even seriously threaten their lives.
Su-Zhen Yang, Ming-Hui Peng, Quan Lin, Shi-Wei Guan, Kai-Lun Zhang, Hai-Bo Yu   +5 more
doaj   +1 more source