Results 191 to 200 of about 142,519 (301)

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

open access: yesRare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang   +7 more
wiley   +1 more source

Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19F MRI Feasibility

open access: yesSmall, EarlyView.
A key challenge in advancing messenger RNA (mRNA) therapeutics in cardiovascular diseases lies in achieving controlled release at the precise site within the vasculature. This study presents the development of perfluorocarbon nanodroplets with exceptional theranostic potential, enabling real‐time tracking through ultrasound and fluorine‐19 (19F ...
Haikun Liu   +14 more
wiley   +1 more source

A new strategy of construction of porcine myocardial infarction model for preclinical research

open access: yesVIEW, EarlyView.
This study proposes a strategy based on the anatomical classification of the porcine left coronary artery (LCA) to establish a stable and reproducible myocardial infarction (MI) model for preclinical research. A combination of LCA classification into nine types via angiography, screening of candidate subtypes, and application of a novel embolic ...
Shixing Huang   +10 more
wiley   +1 more source

Hormone Replacement Therapy Uptake and Discontinuation Trends From 1996‐2023: An Observational Study of the Welsh Population

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To analyse prescribing trends for oral and transdermal hormone replacement therapy (HRT) in Wales from 1996 to 2023, including predictors of discontinuation within one year of initiation. Design Observational study using the Secure Anonymised Information Linkage (SAIL) databank.
Robin Andrews   +3 more
wiley   +1 more source

A Core Outcome Set to Guide Future Research on Caesarean Scar Ectopic Pregnancy: COSCAR Consensus Study

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To develop a core outcome set (COS) for research on caesarean scar ectopic pregnancy (CSEP) treatment. Design Consensus development study. Setting International. Population Healthcare professionals, researchers, patient advocates, or individuals with lived experience of CSEP.
Simrit Nijjar   +11 more
wiley   +1 more source

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