Results 91 to 100 of about 2,478,930 (305)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Development of Prototype of Deep Water Vertical Manifold Connector
Shiyou jixie, 2019 Since the key equipment of the subsea production system being monopolized by foreign companies, taking the vertical connector used in the typical gas field of Liwan 3-1 in the South China Sea as the research object, the prototype of the deep water ...
Meng Xian +4 more
doaj
Journal of Rock Mechanics and Geotechnical EngineeringThe deep underground engineering will face high-temperature and ultrahigh-pressure (HTUP) condition. Indoor triaxial testing is an important means to investigate this challenge in rock mechanics and rock engineering.
Heng Gao +7 more
doaj +1 more source
North Atlantic Deep Water Formation [PDF]
Various studies concerning differing aspects of the North Atlantic are presented. The three major topics under which the works are classified include: (1) oceanography; (2) paleoclimate; and (3) ocean, ice and climate ...
Bennett, T., Broecker, W. S., Hansen, J.
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Materials Today BioImmunotherapy is a cornerstone in cancer treatment, celebrated for its precision, ability to eliminate residual cancer cells, and potential to avert tumor recurrence. Nonetheless, its effectiveness is frequently undermined by the immunosuppressive milieu
Zhimin Bai +10 more
doaj +1 more source
An update of a simulation study of passively heated residemtial buildings [PDF]
, 2016 A simulation study of passively heated residential buildings” published in Procedia Engineering 2015 showed how circulating 15-17ºC water from a 50-m deep U-tube to a floor radiator and solar-heated water from a 30 evacuated tube solar collector and a 2 ...
Abdullah, Mohammad Omar +2 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Theory of small aspect ratio waves in deep water
, 2005 In the limit of small values of the aspect ratio parameter (or wave steepness) which measures the amplitude of a surface wave in units of its wave-length, a model equation is derived from the Euler system in infinite depth (deep water) without potential ...
Benney +25 more
core +3 more sources